Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer

Long noncoding RNA HOTTIP plays important roles in the generation and progression of human cancers. Exosomes participate in cellular communication by transmitting moleculars between cells and are regarded as suitable candidates for non-invasive diagnosis. However, the existence of HOTTIP in the circ...

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Bibliographic Details
Published in:Molecular cancer 2018-02, Vol.17 (1), p.68-68, Article 68
Main Authors: Zhao, Rui, Zhang, Yanli, Zhang, Xin, Yang, Yongmei, Zheng, Xin, Li, Xiaohui, Liu, Yingjie, Zhang, Yi
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers, Tumor
Development and progression
Diagnosis
Disease Progression
Exosomes - metabolism
Female
Gastric cancer
Gene Expression Regulation, Neoplastic
HOTTIP
Humans
Letter to the Editor
Long noncoding RNA
Male
Neoplasm Staging
Prognosis
RNA
RNA, Long Noncoding - genetics
ROC Curve
Stomach cancer
Stomach Neoplasms - diagnosis
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - mortality
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Summary:Long noncoding RNA HOTTIP plays important roles in the generation and progression of human cancers. Exosomes participate in cellular communication by transmitting moleculars between cells and are regarded as suitable candidates for non-invasive diagnosis. However, the existence of HOTTIP in the circulating exosomes and the potential roles of exosomal HOTTIP in gastric cancer (GC) was poorly understood. This study aims at investigating the clinical roles of exosomal HOTTIP in GC. Serum exosomal HOTTIP from 246 subjects (126 GC patients and 120 healthy people) were detected by reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). Our results showed that expression levels of exosomal HOTTIP were typically upregulated in GC than in normal control (P 
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-018-0817-x