Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients

• Published in: BMC nephrology 2023-07, Vol.24 (1), p.206-206, Article 206
• Main Authors: Than, Win Hlaing, Chan, Gordon Chun-Kau, Kwan, Bonnie Ching-Ha, Lai, Ka-Bik, Chan, Ronald Cheong-Kin, Teoh, Jeromy Yuen Chun, Ng, Jack Kit-Chung, Fung, Winston Wing-Shing, Chow, Kai-Ming, Cheng, Phyllis Mei-Shan, Li, Philip Kam-Tao, Szeto, Cheuk-Chun
• Format: Article
• Language: English
• Subjects: Adipokines; Adipose tissue; Aged; Anthropometry; Atherosclerosis; Body fat; Body mass index; Cardiovascular diseases; Care and treatment; Chronic kidney failure; Clinical outcomes; Continuous ambulatory peritoneal dialysis; Creatinine; Diabetes; Diabetes mellitus; Dialysate; Female; Glucose; Glucose metabolism; Health aspects; Hemodialysis; Humans; Inflammation; Insulin Resistance; Kidney diseases; Kidney transplants; Lipid metabolism; Male; Measurement; Metabolic syndrome; Middle Aged; Mortality; Nephrology; Nutritional status; Obesity; Overweight; Patient outcomes; Patients; Peritoneal Dialysis; Peritoneum; Plasma; Prevention; Renal Dialysis; Renal failure; Risk factors; Serine; Serpins - blood; Spectroscopy; Spectrum analysis; Statistical analysis; Survival; Survival analysis; Variance analysis; Velocity
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-023-03259-2

Vaspin is an adipokine that regulates glucose and lipid metabolism. Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. We recruited 146 incident PD patients. Their baseline plasma vaspin levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, dialysis adequacy, and nutritional indices were measured. They were followed for up to 5 years for survival analysis. The average age was 58.4 ± 11.8 years; 96 patients (65.8%) were men, and 90 (61.6%) had diabetes. The median vaspin level was 0.18 ng/dL (interquartile range [IQR] 0.11 to 0.30 ng/dL). Plasma vaspin level did not have a significant correlation with adipose tissue mass or baseline insulin level. However, plasma vaspin level had a modest correlation with the change in insulin resistance, as represented by the HOMA-IR index, in non-diabetic patients (r = -0.358, p = 0.048). Although the plasma vaspin level quartile did not have a significant association with patient survival in the entire cohort, it had a significant interaction with diabetic status (p