Bioluminescence Imaging of Stem Cell-Based Therapeutics for Vascular Regeneration

Stem cell-based therapeutics show promise for treatment of vascular diseases. However, the survival of the cells after in vivo injection into diseased tissues remains a concern. In the advent of non-invasive optical imaging techniques such as bioluminescence imaging (BLI), cell localization and surv...

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Bibliographic Details
Published in:Theranostics 2012-01, Vol.2 (1), p.346-354
Main Author: Ngan F. Huang, Janet Okogbaa, Anna Babakhanyan, John P. Cooke
Format: Article
Language:English
Online Access:Get full text
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Summary:Stem cell-based therapeutics show promise for treatment of vascular diseases. However, the survival of the cells after in vivo injection into diseased tissues remains a concern. In the advent of non-invasive optical imaging techniques such as bioluminescence imaging (BLI), cell localization and survival can be easily monitored over time. This approach has recently been applied towards monitoring stem cell treatments for vascular regeneration of the coronary or peripheral arteries. In this review, we will describe the application of BLI for tracking transplanted stem cells and associating their viability with therapeutic efficacy, in preclinical disease models of vascular disease.
ISSN:1838-7640
1838-7640