Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia

Recent evidence suggests that CD4+CD25+FoxP3+ regulatory T-cells (Treg) may be responsible for the failure of host anti-tumour immunity by suppressing cytotoxic T- cells. We assessed the prognostic significance of tumour infiltrating lymphocytes (TIL) in intestinal-type gastric cardiac cancer. Tumou...

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Bibliographic Details
Published in:BMC gastroenterology 2009-09, Vol.9 (1), p.65-65, Article 65
Main Authors: Haas, Matthias, Dimmler, Arno, Hohenberger, Werner, Grabenbauer, Gerhard G, Niedobitek, Gerald, Distel, Luitpold V
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - pathology
Aged
Cardia - pathology
Care and treatment
Forkhead Transcription Factors - metabolism
Humans
Kaplan-Meier Estimate
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Lymphocytes - pathology
Macrophages - pathology
Middle Aged
Multivariate Analysis
Patient outcomes
Physiological aspects
Prognosis
Retrospective Studies
Risk factors
Stomach cancer
Stomach Neoplasms - diagnosis
Stomach Neoplasms - pathology
Stromal Cells - pathology
T cells
T-Lymphocytes, Regulatory - metabolism
T-Lymphocytes, Regulatory - pathology
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Summary:Recent evidence suggests that CD4+CD25+FoxP3+ regulatory T-cells (Treg) may be responsible for the failure of host anti-tumour immunity by suppressing cytotoxic T- cells. We assessed the prognostic significance of tumour infiltrating lymphocytes (TIL) in intestinal-type gastric cardiac cancer. Tumour infiltrating lymphocyte (TIL) subsets and tumour infiltrating macrophages (TIM) were investigated in 52 cases using tissue microarrays. The interrelationship between the cell populations (CD3+, CD8+, CD20+, CD68+, GranzymeB+, FoxP3+) in different compartments and NED-survival was investigated (median follow-up time: 61 months). Intraepithelial infiltration with TIL and TIM including Treg was generally low and not related to NED-survival. However, patients with large numbers of FoxP3+ Treg in the tumour stroma (>125.9 FoxP3+TILs/mm2) had a median survival time of 58 months while those with low FoxP3+ TIL counts (
ISSN:1471-230X
1471-230X
DOI:10.1186/1471-230X-9-65