Low-intensity extracorporeal shock wave therapy for Peyroniès disease: a systematic review and meta-analysis

A systematic review of the evidence was conducted to assess the efficacy of low-intensity extracorporeal shock wave therapy (LI-ESWT) for patients with Peyronie`s Disease (PD). A comprehensive search of the Cochrane Registry, PubMed and Embase databases was conducted to identify all controlled trial...

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Published in:BMC urology 2024-10, Vol.24 (1), p.217-10, Article 217
Main Authors: Li, Guizhong, Xu, Xiao, Man, Libo
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Clinical trials
Collaboration
Controlled trial
Erectile dysfunction
Erection
Extracorporeal Shockwave Therapy - methods
Humans
Lithotripsy
Male
Medical equipment
Medical research
Medicine, Experimental
Meta-analysis
Pain
Patients
Penile deviation
Penile Induration - therapy
Penis
Peyronie’s disease
Plaque
Plaques
Remission
Remission (Medicine)
Sexual disorders
Shock waves
Statistical analysis
Treatment Outcome
Visual perception
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Man, Libo
description A systematic review of the evidence was conducted to assess the efficacy of low-intensity extracorporeal shock wave therapy (LI-ESWT) for patients with Peyronie`s Disease (PD). A comprehensive search of the Cochrane Registry, PubMed and Embase databases was conducted to identify all controlled trials, including randomised controlled trials (RCTs), cohort studies and case-control studies, focusing on the efficacy of LI-ESWT in treating PD, and published before February 2023. The size of plaques, curvature deviation, visual analog scale [VAS] and International Index of Erectile Function (IIEF) were the most commonly used tool to evaluate the treatment effectiveness of LI-ESWT. There were 7 studies including  475 patients from 1999 to 2023. The meta-analysis of the data revealed that LI-ESWT could considerably enhance the proportion of men experiencing a reduction in penile plaques (RD 0.27, 95% CI: 0.04-0.50, P = 0.02), improvement in penile curvature (RD: 0.13; 95% CI, 0-0.26; p = 0.05), alleviation of pain (RD 0.22, 95% CI: 0.01-0.42, P = 0.04), and complete remission (RD 0.38, 95% CI 0.23-0.52, P 
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A comprehensive search of the Cochrane Registry, PubMed and Embase databases was conducted to identify all controlled trials, including randomised controlled trials (RCTs), cohort studies and case-control studies, focusing on the efficacy of LI-ESWT in treating PD, and published before February 2023. The size of plaques, curvature deviation, visual analog scale [VAS] and International Index of Erectile Function (IIEF) were the most commonly used tool to evaluate the treatment effectiveness of LI-ESWT. There were 7 studies including  475 patients from 1999 to 2023. The meta-analysis of the data revealed that LI-ESWT could considerably enhance the proportion of men experiencing a reduction in penile plaques (RD 0.27, 95% CI: 0.04-0.50, P = 0.02), improvement in penile curvature (RD: 0.13; 95% CI, 0-0.26; p = 0.05), alleviation of pain (RD 0.22, 95% CI: 0.01-0.42, P = 0.04), and complete remission (RD 0.38, 95% CI 0.23-0.52, P &lt; 0.00001). However, there were no significant differences in improvement of sexual function (MD: 1.44; 95% CI, -3.10-5.97; p = 0.53) between LI-ESWT and the placebo group. According to these studies, LI-ESWT has the potential to decrease plaque size and improve penile curvature or pain in men with PD. 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A comprehensive search of the Cochrane Registry, PubMed and Embase databases was conducted to identify all controlled trials, including randomised controlled trials (RCTs), cohort studies and case-control studies, focusing on the efficacy of LI-ESWT in treating PD, and published before February 2023. The size of plaques, curvature deviation, visual analog scale [VAS] and International Index of Erectile Function (IIEF) were the most commonly used tool to evaluate the treatment effectiveness of LI-ESWT. There were 7 studies including  475 patients from 1999 to 2023. The meta-analysis of the data revealed that LI-ESWT could considerably enhance the proportion of men experiencing a reduction in penile plaques (RD 0.27, 95% CI: 0.04-0.50, P = 0.02), improvement in penile curvature (RD: 0.13; 95% CI, 0-0.26; p = 0.05), alleviation of pain (RD 0.22, 95% CI: 0.01-0.42, P = 0.04), and complete remission (RD 0.38, 95% CI 0.23-0.52, P &lt; 0.00001). However, there were no significant differences in improvement of sexual function (MD: 1.44; 95% CI, -3.10-5.97; p = 0.53) between LI-ESWT and the placebo group. According to these studies, LI-ESWT has the potential to decrease plaque size and improve penile curvature or pain in men with PD. The publication of robust evidence from additional well-designed long-term multicenter randomized controlled trials would provide more confidence regarding use of these devices in patients with PD.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39375617</pmid><doi>10.1186/s12894-024-01607-4</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Analysis
Care and treatment
Clinical trials
Collaboration
Controlled trial
Erectile dysfunction
Erection
Extracorporeal Shockwave Therapy - methods
Humans
Lithotripsy
Male
Medical equipment
Medical research
Medicine, Experimental
Meta-analysis
Pain
Patients
Penile deviation
Penile Induration - therapy
Penis
Peyronie’s disease
Plaque
Plaques
Remission
Remission (Medicine)
Sexual disorders
Shock waves
Statistical analysis
Treatment Outcome
Visual perception
title Low-intensity extracorporeal shock wave therapy for Peyroniès disease: a systematic review and meta-analysis
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