Retrospective Analysis of Risk Factors for Venous Thromboembolism in 283 Patients with Lung Cancer during Systemic Therapy

Patients with lung cancer have high risk of developing venous thromboembolism (VTE), which has been shown to have a significant impact on mortality. This study was to identify the incidence of VTE in lung cancer patients during systemic therapy and to analyze the risk factors associated with it. We...

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Bibliographic Details
Published in:Zhongguo fei ai za zhi 2019-07, Vol.22 (7), p.419-426
Main Authors: Liu, Yan'e, Gu, Yangchun, Yi, Fumei, Cao, Baoshan
Format: Article
Language:Chinese
Subjects:
Adult
Aged
Aged, 80 and over
Blood
Cancer therapies
Chemotherapy
D-dimer
Early Diagnosis
Epidemiology
Female
Health risk assessment
Hormone replacement therapy
Humans
Kidney diseases
Lower extremity varicose vein
Lung cancer
Lung neoplasms
Lung Neoplasms - blood
Lung Neoplasms - complications
Lung Neoplasms - therapy
Male
Middle Aged
Multivariate Analysis
Prognosis
Retrospective Studies
Risk Factors
Surgery
Systematic review
Systemic therapy
Thoracic surgery
Thromboembolism
Thrombosis
Venous thromboembolism
Venous Thromboembolism - complications
Venous Thromboembolism - diagnosis
Young Adult
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Summary:Patients with lung cancer have high risk of developing venous thromboembolism (VTE), which has been shown to have a significant impact on mortality. This study was to identify the incidence of VTE in lung cancer patients during systemic therapy and to analyze the risk factors associated with it. We retrospectively analyzed the cases of 283 patients with lung cancer who received systemic therapy in the Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, from January 2016 to December 2018. Chi-square test and multivariate analyses were used to assess the correlation between clinical features and VTE. Of the patients we observed, 34 developed VTE, with an incidence of 12.01% (34/283). In patients with lower extremity varicose vein (LVV), there was an increase in the incidence of VTE (50.00% vs 9.89%, P=0.001). The incidence VTE in patients with distant metastasis was higher than that in patients without distant metastasis, and higher than that in patients with tumor-free (14.
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2019.07.03