Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

Behçet's disease is a systemic inflammatory disorder of unknown etiology. The disease manifests with diverse clinical symptoms, most commonly recurrent oral and genital ulcers, skin lesions, and uveitis, though it can affect multiple organ systems. Diagnosis is primarily clinical due to the lac...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2024-04, Vol.60 (4), p.562
Main Authors: Lavalle, Salvatore, Caruso, Sebastiano, Foti, Roberta, Gagliano, Caterina, Cocuzza, Salvatore, La Via, Luigi, Parisi, Federica Maria, Calvo-Henriquez, Christian, Maniaci, Antonino
Format: Article
Language:English
Subjects:
Adalimumab
Adrenal Cortex Hormones - therapeutic use
Arthritis
Behcet Syndrome - complications
Behcet Syndrome - diagnosis
Behcet Syndrome - drug therapy
Behcet Syndrome - physiopathology
Behcet Syndrome - therapy
Behçet’s disease
Cytokines
Development and progression
Diagnosis
Epidemiology
Erythema
Humans
Immunology
Immunosuppressive agents
Immunosuppressive Agents - therapeutic use
Inflammation
Medical research
Medicine, Experimental
Nervous system
Pathogenesis
pathogenesis clinical features
Patients
Skin
Thrombosis
treatment approaches
Ulcers
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Summary:Behçet's disease is a systemic inflammatory disorder of unknown etiology. The disease manifests with diverse clinical symptoms, most commonly recurrent oral and genital ulcers, skin lesions, and uveitis, though it can affect multiple organ systems. Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. Current treatment strategies involve corticosteroids, immunosuppressive agents, and, increasingly, biological therapies. Behçet's disease exhibits a higher prevalence along the Silk Road, suggesting a role of environmental and genetic factors. Despite significant progress in understanding its clinical characteristics and treatment approaches, gaps remain in our understanding of its pathogenesis. Future research is needed to elucidate the disease's pathophysiology and optimize treatment strategies.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina60040562