Clinical considerations in the management of hidradenitis suppurativa in women

Hidradenitis suppurativa (HS) is a chronic, inflammatory disease of the skin with a predilection for women. The role of sex hormones, including estrogen and progesterone, is incompletely understood, but alterations in hormone levels may play a role in disease activity for many patients. Specific cli...

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Bibliographic Details
Published in:International journal of women's dermatology 2021-12, Vol.7 (5), p.664-671
Main Authors: Kozera, Emily K., Lowes, Michelle A., Hsiao, Jennifer L., Frew, John W.
Format: Article
Language:English
Subjects:
breastfeeding
childbirth
estrogen
Hidradenitis suppurativa
hormones
menopause
progesterone
psychosexual function
quality of life
Review
women
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Summary:Hidradenitis suppurativa (HS) is a chronic, inflammatory disease of the skin with a predilection for women. The role of sex hormones, including estrogen and progesterone, is incompletely understood, but alterations in hormone levels may play a role in disease activity for many patients. Specific clinical considerations should be made for women with HS, particularly in the setting of pregnancy, childbirth, breastfeeding, and menopause. Current knowledge gaps regarding HS include the cumulative impact of disease across an individual's lifespan, as well as the mechanistic role of sex hormones in the disease. An improved understanding of the pathophysiologic role of hormones in HS would optimize our ability to use targeted therapies for hormonally driven disease. Psychological and psychosexual support for women with HS is an important facet of any holistic management strategy for the disease. This article integrates up-to-date pathogenic and mechanistic insights with evidence-based clinical management to optimize care for women with HS.
ISSN:2352-6475
2352-6475
DOI:10.1016/j.ijwd.2021.10.012