Stimuli-Responsive Hydrogels for Protein Delivery

Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompat...

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Bibliographic Details
Published in:Gels 2023-10, Vol.9 (10), p.802
Main Authors: Malta, Rafaela, Marques, Ana Camila, Costa, Paulo Cardoso da, Amaral, Maria Helena
Format: Article
Language:English
Subjects:
Amino acids
Bioavailability
Biocompatibility
Biological activity
Controlled release
Cost control
Drug delivery systems
Drugs
Enzymes
FDA approval
Health aspects
Hydrogels
Linaclotide
Lymphatic system
Metabolism
Molecular weight
Monoclonal antibodies
Patient compliance
Peptides
Pharmacology
Physiochemistry
protein delivery
Proteins
Review
Signal transduction
Stimuli
stimuli-responsive hydrogels
Type 2 diabetes
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Summary:Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompatibility, their porous structure, which enables the transport of various peptides and proteins, and their protective effect against degradation, hydrogels have gained prominence as ideal carriers for these molecules’ delivery. Particularly, stimuli-responsive hydrogels exhibit physicochemical transitions in response to subtle modifications in the surrounding environment, leading to the controlled release of entrapped proteins or peptides. This review is focused on the application of these hydrogels in protein and peptide delivery, including a brief overview of therapeutic proteins and types of stimuli-responsive polymers.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels9100802