Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase

Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000...

Full description

Saved in:
Bibliographic Details
Published in:TheScientificWorld 2012-01, Vol.2012 (2012), p.1-6
Main Authors: Quijano-Hernández, Israel A., Castro-Barcena, Alejandro, Aparicio-Burgos, Esteban, Barbosa-Mireles, Marco A., Cruz-Chan, Julio V., Vázquez-Chagoyán, Juan C., Bolio-González, M. E., Dumonteil, Eric
Format: Article
Language:English
Subjects:
Animals
Chagas disease
Chagas Disease - immunology
Chagas Disease - pathology
Chagas Disease - physiopathology
Chagas Disease - veterinary
Cysts
Dog Diseases - immunology
Dog Diseases - parasitology
Dog Diseases - pathology
Dog Diseases - physiopathology
Dogs
Electrocardiography
Health aspects
Heart diseases
Immunoglobulin G
Lesions
Mortality
Myocarditis
Observations
Parasites
Protozoa
Seroconversion
Trypanosoma cruzi
Trypanosoma cruzi - pathogenicity
Trypomastigotes
Vector-borne diseases
Virulence (Microbiology)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1 via intraperitoneal). Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated. All three doses of this strain of T. cruzi induced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis. Specific anti-T. cruzi IgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation. Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg-1. Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain of T. cruzi.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1100/2012/635169