Loading…

Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase

Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000...

Full description

Saved in:
Bibliographic Details
Published in:TheScientificWorld 2012-01, Vol.2012 (2012), p.1-6
Main Authors: Quijano-Hernández, Israel A., Castro-Barcena, Alejandro, Aparicio-Burgos, Esteban, Barbosa-Mireles, Marco A., Cruz-Chan, Julio V., Vázquez-Chagoyán, Juan C., Bolio-González, M. E., Dumonteil, Eric
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c632t-29935456de3157403d336b3d7aa13d24cc7808dfa260913eb91600ded707e2573
cites cdi_FETCH-LOGICAL-c632t-29935456de3157403d336b3d7aa13d24cc7808dfa260913eb91600ded707e2573
container_end_page 6
container_issue 2012
container_start_page 1
container_title TheScientificWorld
container_volume 2012
creator Quijano-Hernández, Israel A.
Castro-Barcena, Alejandro
Aparicio-Burgos, Esteban
Barbosa-Mireles, Marco A.
Cruz-Chan, Julio V.
Vázquez-Chagoyán, Juan C.
Bolio-González, M. E.
Dumonteil, Eric
description Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1 via intraperitoneal). Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated. All three doses of this strain of T. cruzi induced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis. Specific anti-T. cruzi IgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation. Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg-1. Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain of T. cruzi.
doi_str_mv 10.1100/2012/635169
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_c75c4f765e5243739d83bfb45db67d7d</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A382318101</galeid><doaj_id>oai_doaj_org_article_c75c4f765e5243739d83bfb45db67d7d</doaj_id><sourcerecordid>A382318101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c632t-29935456de3157403d336b3d7aa13d24cc7808dfa260913eb91600ded707e2573</originalsourceid><addsrcrecordid>eNqFks-LEzEUgAdR3Lp68qwMeBGlu0lefsxchNLd1cKCHlbwFtIk06bMJDWZqaz_gP-26c5arQiSQ-C9733hvbyieI7RGcYInROEyTkHhnn9oJhgBmIqKP3ysJgQYHzKMUUnxZOUNghBJTB7XJwQwqioazwpflzuVDuo3gVfhqact847rdpSeVMuum7wYav6dWjD6i58ZVU_RJv27IVrGhut78uFb6zu3c6WFyGNyZt4u1U-pNCpUsfhuyudz9lVKs0QnV-V_dqWMz30tvy0Vsk-LR41qk322f19Wny-uryZf5hef3y_mM-up5oD6aekroFRxo0FzARFYAD4EoxQCoMhVGtRoco0inBUY7DLGnOEjDUCCUuYgNNiMXpNUBu5ja5T8VYG5eRdIMSVVLF3urVSC6ZpIzizjFAQUJsKls2SMrPkwgiTXe9G13ZYdtboPIqo2iPpcca7tVyFnQQgAIxlwet7QQxfB5t62bmkbdsqb8OQJEYY8fxnFc7oq7_QTRiiz6OSBAGnSFDgv6mVyg0434T8rt5L5QwqArjKykyd_YPKx9jO6eBt43L8qODtWKBjSCna5tAjRnK_g3K_g3LcwUy__HMsB_bX0mXgzQisnTfqm_uP7cUI24zYRh1gWuUshp9KPuvS</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036407436</pqid></control><display><type>article</type><title>Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase</title><source>Open Access: PubMed Central</source><source>Wiley Online Library Open Access</source><source>Publicly Available Content Database</source><creator>Quijano-Hernández, Israel A. ; Castro-Barcena, Alejandro ; Aparicio-Burgos, Esteban ; Barbosa-Mireles, Marco A. ; Cruz-Chan, Julio V. ; Vázquez-Chagoyán, Juan C. ; Bolio-González, M. E. ; Dumonteil, Eric</creator><contributor>Lima, Regina ; Regina Lima</contributor><creatorcontrib>Quijano-Hernández, Israel A. ; Castro-Barcena, Alejandro ; Aparicio-Burgos, Esteban ; Barbosa-Mireles, Marco A. ; Cruz-Chan, Julio V. ; Vázquez-Chagoyán, Juan C. ; Bolio-González, M. E. ; Dumonteil, Eric ; Lima, Regina ; Regina Lima</creatorcontrib><description>Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1 via intraperitoneal). Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated. All three doses of this strain of T. cruzi induced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis. Specific anti-T. cruzi IgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation. Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg-1. Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain of T. cruzi.</description><identifier>ISSN: 2356-6140</identifier><identifier>ISSN: 1537-744X</identifier><identifier>EISSN: 1537-744X</identifier><identifier>DOI: 10.1100/2012/635169</identifier><identifier>PMID: 22547991</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Chagas disease ; Chagas Disease - immunology ; Chagas Disease - pathology ; Chagas Disease - physiopathology ; Chagas Disease - veterinary ; Cysts ; Dog Diseases - immunology ; Dog Diseases - parasitology ; Dog Diseases - pathology ; Dog Diseases - physiopathology ; Dogs ; Electrocardiography ; Health aspects ; Heart diseases ; Immunoglobulin G ; Lesions ; Mortality ; Myocarditis ; Observations ; Parasites ; Protozoa ; Seroconversion ; Trypanosoma cruzi ; Trypanosoma cruzi - pathogenicity ; Trypomastigotes ; Vector-borne diseases ; Virulence (Microbiology)</subject><ispartof>TheScientificWorld, 2012-01, Vol.2012 (2012), p.1-6</ispartof><rights>Copyright © 2012 Israel A. Quijano-Hernández et al.</rights><rights>COPYRIGHT 2012 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2012 Israel A. Quijano-Hernández et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c632t-29935456de3157403d336b3d7aa13d24cc7808dfa260913eb91600ded707e2573</citedby><cites>FETCH-LOGICAL-c632t-29935456de3157403d336b3d7aa13d24cc7808dfa260913eb91600ded707e2573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2036407436/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2036407436?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22547991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lima, Regina</contributor><contributor>Regina Lima</contributor><creatorcontrib>Quijano-Hernández, Israel A.</creatorcontrib><creatorcontrib>Castro-Barcena, Alejandro</creatorcontrib><creatorcontrib>Aparicio-Burgos, Esteban</creatorcontrib><creatorcontrib>Barbosa-Mireles, Marco A.</creatorcontrib><creatorcontrib>Cruz-Chan, Julio V.</creatorcontrib><creatorcontrib>Vázquez-Chagoyán, Juan C.</creatorcontrib><creatorcontrib>Bolio-González, M. E.</creatorcontrib><creatorcontrib>Dumonteil, Eric</creatorcontrib><title>Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase</title><title>TheScientificWorld</title><addtitle>ScientificWorldJournal</addtitle><description>Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1 via intraperitoneal). Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated. All three doses of this strain of T. cruzi induced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis. Specific anti-T. cruzi IgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation. Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg-1. Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain of T. cruzi.</description><subject>Animals</subject><subject>Chagas disease</subject><subject>Chagas Disease - immunology</subject><subject>Chagas Disease - pathology</subject><subject>Chagas Disease - physiopathology</subject><subject>Chagas Disease - veterinary</subject><subject>Cysts</subject><subject>Dog Diseases - immunology</subject><subject>Dog Diseases - parasitology</subject><subject>Dog Diseases - pathology</subject><subject>Dog Diseases - physiopathology</subject><subject>Dogs</subject><subject>Electrocardiography</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Immunoglobulin G</subject><subject>Lesions</subject><subject>Mortality</subject><subject>Myocarditis</subject><subject>Observations</subject><subject>Parasites</subject><subject>Protozoa</subject><subject>Seroconversion</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - pathogenicity</subject><subject>Trypomastigotes</subject><subject>Vector-borne diseases</subject><subject>Virulence (Microbiology)</subject><issn>2356-6140</issn><issn>1537-744X</issn><issn>1537-744X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqFks-LEzEUgAdR3Lp68qwMeBGlu0lefsxchNLd1cKCHlbwFtIk06bMJDWZqaz_gP-26c5arQiSQ-C9733hvbyieI7RGcYInROEyTkHhnn9oJhgBmIqKP3ysJgQYHzKMUUnxZOUNghBJTB7XJwQwqioazwpflzuVDuo3gVfhqact847rdpSeVMuum7wYav6dWjD6i58ZVU_RJv27IVrGhut78uFb6zu3c6WFyGNyZt4u1U-pNCpUsfhuyudz9lVKs0QnV-V_dqWMz30tvy0Vsk-LR41qk322f19Wny-uryZf5hef3y_mM-up5oD6aekroFRxo0FzARFYAD4EoxQCoMhVGtRoco0inBUY7DLGnOEjDUCCUuYgNNiMXpNUBu5ja5T8VYG5eRdIMSVVLF3urVSC6ZpIzizjFAQUJsKls2SMrPkwgiTXe9G13ZYdtboPIqo2iPpcca7tVyFnQQgAIxlwet7QQxfB5t62bmkbdsqb8OQJEYY8fxnFc7oq7_QTRiiz6OSBAGnSFDgv6mVyg0434T8rt5L5QwqArjKykyd_YPKx9jO6eBt43L8qODtWKBjSCna5tAjRnK_g3K_g3LcwUy__HMsB_bX0mXgzQisnTfqm_uP7cUI24zYRh1gWuUshp9KPuvS</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Quijano-Hernández, Israel A.</creator><creator>Castro-Barcena, Alejandro</creator><creator>Aparicio-Burgos, Esteban</creator><creator>Barbosa-Mireles, Marco A.</creator><creator>Cruz-Chan, Julio V.</creator><creator>Vázquez-Chagoyán, Juan C.</creator><creator>Bolio-González, M. E.</creator><creator>Dumonteil, Eric</creator><general>Hindawi Puplishing Corporation</general><general>The Scientific World Journal</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120101</creationdate><title>Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase</title><author>Quijano-Hernández, Israel A. ; Castro-Barcena, Alejandro ; Aparicio-Burgos, Esteban ; Barbosa-Mireles, Marco A. ; Cruz-Chan, Julio V. ; Vázquez-Chagoyán, Juan C. ; Bolio-González, M. E. ; Dumonteil, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c632t-29935456de3157403d336b3d7aa13d24cc7808dfa260913eb91600ded707e2573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Chagas disease</topic><topic>Chagas Disease - immunology</topic><topic>Chagas Disease - pathology</topic><topic>Chagas Disease - physiopathology</topic><topic>Chagas Disease - veterinary</topic><topic>Cysts</topic><topic>Dog Diseases - immunology</topic><topic>Dog Diseases - parasitology</topic><topic>Dog Diseases - pathology</topic><topic>Dog Diseases - physiopathology</topic><topic>Dogs</topic><topic>Electrocardiography</topic><topic>Health aspects</topic><topic>Heart diseases</topic><topic>Immunoglobulin G</topic><topic>Lesions</topic><topic>Mortality</topic><topic>Myocarditis</topic><topic>Observations</topic><topic>Parasites</topic><topic>Protozoa</topic><topic>Seroconversion</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - pathogenicity</topic><topic>Trypomastigotes</topic><topic>Vector-borne diseases</topic><topic>Virulence (Microbiology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quijano-Hernández, Israel A.</creatorcontrib><creatorcontrib>Castro-Barcena, Alejandro</creatorcontrib><creatorcontrib>Aparicio-Burgos, Esteban</creatorcontrib><creatorcontrib>Barbosa-Mireles, Marco A.</creatorcontrib><creatorcontrib>Cruz-Chan, Julio V.</creatorcontrib><creatorcontrib>Vázquez-Chagoyán, Juan C.</creatorcontrib><creatorcontrib>Bolio-González, M. E.</creatorcontrib><creatorcontrib>Dumonteil, Eric</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>TheScientificWorld</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quijano-Hernández, Israel A.</au><au>Castro-Barcena, Alejandro</au><au>Aparicio-Burgos, Esteban</au><au>Barbosa-Mireles, Marco A.</au><au>Cruz-Chan, Julio V.</au><au>Vázquez-Chagoyán, Juan C.</au><au>Bolio-González, M. E.</au><au>Dumonteil, Eric</au><au>Lima, Regina</au><au>Regina Lima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase</atitle><jtitle>TheScientificWorld</jtitle><addtitle>ScientificWorldJournal</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2356-6140</issn><issn>1537-744X</issn><eissn>1537-744X</eissn><abstract>Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1 via intraperitoneal). Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated. All three doses of this strain of T. cruzi induced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis. Specific anti-T. cruzi IgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation. Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg-1. Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain of T. cruzi.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>22547991</pmid><doi>10.1100/2012/635169</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2356-6140
ispartof TheScientificWorld, 2012-01, Vol.2012 (2012), p.1-6
issn 2356-6140
1537-744X
1537-744X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_c75c4f765e5243739d83bfb45db67d7d
source Open Access: PubMed Central; Wiley Online Library Open Access; Publicly Available Content Database
subjects Animals
Chagas disease
Chagas Disease - immunology
Chagas Disease - pathology
Chagas Disease - physiopathology
Chagas Disease - veterinary
Cysts
Dog Diseases - immunology
Dog Diseases - parasitology
Dog Diseases - pathology
Dog Diseases - physiopathology
Dogs
Electrocardiography
Health aspects
Heart diseases
Immunoglobulin G
Lesions
Mortality
Myocarditis
Observations
Parasites
Protozoa
Seroconversion
Trypanosoma cruzi
Trypanosoma cruzi - pathogenicity
Trypomastigotes
Vector-borne diseases
Virulence (Microbiology)
title Evaluation of Clinical and Immunopathological Features of Different Infective Doses of Trypanosoma cruzi in Dogs during the Acute Phase
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A03%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20Clinical%20and%20Immunopathological%20Features%20of%20Different%20Infective%20Doses%20of%20Trypanosoma%20cruzi%20in%20Dogs%20during%20the%20Acute%20Phase&rft.jtitle=TheScientificWorld&rft.au=Quijano-Hern%C3%A1ndez,%20Israel%20A.&rft.date=2012-01-01&rft.volume=2012&rft.issue=2012&rft.spage=1&rft.epage=6&rft.pages=1-6&rft.issn=2356-6140&rft.eissn=1537-744X&rft_id=info:doi/10.1100/2012/635169&rft_dat=%3Cgale_doaj_%3EA382318101%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c632t-29935456de3157403d336b3d7aa13d24cc7808dfa260913eb91600ded707e2573%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2036407436&rft_id=info:pmid/22547991&rft_galeid=A382318101&rfr_iscdi=true