Safety of Ovarian Tissue Autotransplantation for Cancer Patients

Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technolo...

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Bibliographic Details
Published in:Obstetrics and Gynecology International 2012-01, Vol.2012 (2012), p.233-238
Main Authors: Englert, Yvon, Dechene, Julie, Tsepelidis, Sophie, Bockstaele, Laurence, Demeestere, Isabelle
Format: Article
Language:English
Subjects:
Review
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Summary:Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technologies. However, human ovarian tissue is generally harvested before the administration of gonadotoxic treatment and could be contaminated with malignant cells. The safety of autotransplantation of ovarian cortex remains a major concern for fertility preservation units worldwide. This paper discusses the main tools for detecting disseminated cancer cells currently available, their limitations, and clinical relevance.
ISSN:1687-9589
1687-9597
1687-9589
DOI:10.1155/2012/495142