Safety of Ovarian Tissue Autotransplantation for Cancer Patients

Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technolo...

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Published in:Obstetrics and Gynecology International 2012-01, Vol.2012 (2012), p.233-238
Main Authors: Englert, Yvon, Dechene, Julie, Tsepelidis, Sophie, Bockstaele, Laurence, Demeestere, Isabelle
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cited_by cdi_FETCH-LOGICAL-a569t-5dd03a09575ac9c5daf3325d1ce15f594fbf37477bbadfcaa5c80303922bbe473
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description Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technologies. However, human ovarian tissue is generally harvested before the administration of gonadotoxic treatment and could be contaminated with malignant cells. The safety of autotransplantation of ovarian cortex remains a major concern for fertility preservation units worldwide. This paper discusses the main tools for detecting disseminated cancer cells currently available, their limitations, and clinical relevance.
doi_str_mv 10.1155/2012/495142
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title Safety of Ovarian Tissue Autotransplantation for Cancer Patients
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