HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality

Highlights • RBP is a marker of vitamin-A status and a negative acute-phase protein. • This is the largest study of interactions between schistosomiasis and HIV. • RBP was negatively correlated with markers of HIV progression and inflammation. • RBP was lower in those co-infected with HIV and S. man...

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Bibliographic Details
Published in:International journal of infectious diseases 2015-04, Vol.33 (C), p.159-164
Main Authors: Kotzé, Sebastian Ranzi, Zinyama-Gutsire, Rutendo, Kallestrup, Per, Benn, Christine Stabell, Gomo, Exnevia, Gerstoft, Jan, van Dam, Govert, Mortensen, Ole Hartvig, Ullum, Henrik, Erikstrup, Christian
Format: Article
Language:English
Subjects:
Adult
Africa
Biomarkers - blood
Coinfection - diagnosis
Coinfection - mortality
Cytokines - blood
Disease Progression
Female
HIV
HIV Infections - complications
HIV Infections - diagnosis
HIV Infections - mortality
Humans
Infectious Disease
Inflammation - immunology
Inflammation - virology
Male
Middle Aged
mortality
Pulmonary/Respiratory
Retinol-binding protein
Retinol-Binding Proteins, Plasma - analysis
Rural Population
schistosomiasis
Schistosomiasis - complications
Schistosomiasis - diagnosis
vitamin A
Young Adult
Zimbabwe - epidemiology
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Summary:Highlights • RBP is a marker of vitamin-A status and a negative acute-phase protein. • This is the largest study of interactions between schistosomiasis and HIV. • RBP was negatively correlated with markers of HIV progression and inflammation. • RBP was lower in those co-infected with HIV and S. mansoni. • RBP was negatively correlated with schistosomiasis intensity in these individuals.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.01.015