Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation

Being able to track donor reactive T cells during the course of organ transplantation is a key to improve the graft survival, to prevent graft dysfunction, and to adapt the immunosuppressive regimen. The attempts of transplant immunologists have been for long hampered by the large size of the allore...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2016-03, Vol.7, p.89-89
Main Authors: Degauque, Nicolas, Brouard, Sophie, Soulillou, Jean-Paul
Format: Article
Language:English
Subjects:
Alloreactive T-cells
Human health and pathology
Immunology
Life Sciences
MHC
T lymphocytes
tcr
TCR repertoire
Transplantation Immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Being able to track donor reactive T cells during the course of organ transplantation is a key to improve the graft survival, to prevent graft dysfunction, and to adapt the immunosuppressive regimen. The attempts of transplant immunologists have been for long hampered by the large size of the alloreactive T cell repertoire. Understanding how self-TCR can interact with allogeneic MHC is a key to critically appraise the different assays available to analyze the TCR Vβ repertoire usage. In this report, we will review conceptually and experimentally the process of cross-reactivity. We will then highlight what can be learned from allotransplantation, a situation of artificial cross-reactivity. Finally, the low- and high-resolution techniques to characterize the TCR Vβ repertoire usage in transplantation will be critically discussed.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2016.00089