Aktivitas antibakteri n-benzoilamoksisilin dan n-3,4-diklorobenzoilamoksisilin terhadap Staphylococcus ATCC 25923 dan Escherichia coli ATCC 35218

N-Benzolamoxicillin and N-3,4-dichlorobenzolamoxicillin were synthesized from amoxicillin by acylation with benzoylchloride and 3,4-dichlorobenzoylchloride respectively. Structure characterization of the amoxicillin derivative compounds were done by UV, IR and 1H-NMR spectroscopy. Both derivative co...

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Bibliographic Details
Published in:Berkala Penelitian Hayati (Journal of Biological Researchers) 2000-06, Vol.5 (2), p.79-83
Main Authors: Harry Santosa, Bambang Soekardjo, Ami Soewandi J S
Format: Article
Language:English
Subjects:
4-dichlorobenzolamoxicillin
Antibacterial activity
N-3
N-Benzolamoxicillin
Online Access:Get full text
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Summary:N-Benzolamoxicillin and N-3,4-dichlorobenzolamoxicillin were synthesized from amoxicillin by acylation with benzoylchloride and 3,4-dichlorobenzoylchloride respectively. Structure characterization of the amoxicillin derivative compounds were done by UV, IR and 1H-NMR spectroscopy. Both derivative compound has antibacterial antivity against Staphylococcus aureus and Escherichia coli. The activity of N-3,4-dichlorobenzolamoxicillin is more active than N-Benzolamoxicillin.
ISSN:0852-6834
2337-389X
DOI:10.23869/bphjbr.5.2.20004