Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

In recent years, there has been a considerable increase in interest in the use of transgenic plants as sources of valuable secondary metabolites or recombinant proteins. This has been facilitated by the advent of genetic engineering technology with the possibility for direct modification of the expr...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-01, Vol.27 (3), p.795
Main Authors: Kowalczyk, Tomasz, Merecz-Sadowska, Anna, Picot, Laurent, Brčić Karačonji, Irena, Wieczfinska, Joanna, Śliwiński, Tomasz, Sitarek, Przemysław
Format: Article
Language:English
Subjects:
Bacteria
Bioactive compounds
Biochemistry
Biochemistry, Molecular Biology
Biological activity
Bioreactors
Biosynthesis
Biotechnology
Cell Culture Techniques - methods
Gene expression
Genetic engineering
genetic manipulation
Genetically altered foods
Industrial engineering
Industry
Life Sciences
Manufacturing engineering
Medical research
Medication
Metabolism
Metabolites
Pharmaceutical sciences
Plant production
Plants, Genetically Modified - metabolism
Proteins
recombinant proteins
Recombinant Proteins - metabolism
Research projects
Review
Secondary metabolites
Soybeans
transgenic plant cultures
Transgenic plants
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Summary:In recent years, there has been a considerable increase in interest in the use of transgenic plants as sources of valuable secondary metabolites or recombinant proteins. This has been facilitated by the advent of genetic engineering technology with the possibility for direct modification of the expression of genes related to the biosynthesis of biologically active compounds. A wide range of research projects have yielded a number of efficient plant systems that produce specific secondary metabolites or recombinant proteins. Furthermore, the use of bioreactors allows production to be increased to industrial scales, which can quickly and cheaply deliver large amounts of material in a short time. The resulting plant production systems can function as small factories, and many of them that are targeted at a specific operation have been patented. This review paper summarizes the key research in the last ten years regarding the use of transgenic plants as small, green biofactories for the bioreactor-based production of secondary metabolites and recombinant proteins; it simultaneously examines the production of metabolites and recombinant proteins on an industrial scale and presents the current state of available patents in the field.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27030795