Resistance mechanisms to drug therapy in breast cancer and other solid tumors: An opinion [version 1; peer review: 2 approved, 1 approved with reservations]

Cancer is an important contributor to mortality worldwide. Breast cancer is the most common solid tumor in women. Despite numerous drug combinations and regimens, all patients with advanced breast cancer, similarly to other solid tumors, inevitably develop resistance to treatment. Identified mechani...

Full description

Saved in:
Bibliographic Details
Published in:F1000 research 2017, Vol.6, p.288-288
Main Authors: Moiseenko, Fedor V, Volkov, Nikita, Bogdanov, Alexey, Dubina, Michael, Moiseyenko, Vladimir
Format: Article
Language:English
Subjects:
Antimicrobials & Drug Resistance
Breast cancer
Breast Diseases: Benign & Malignant
Opinion
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer is an important contributor to mortality worldwide. Breast cancer is the most common solid tumor in women. Despite numerous drug combinations and regimens, all patients with advanced breast cancer, similarly to other solid tumors, inevitably develop resistance to treatment. Identified mechanisms of resistance could be classified into intra- and extracellular mechanisms. Intracellular mechanisms include drug metabolism and efflux, target modulations and damage restoration. Extracellular mechanisms might be attributed to the crosstalk between tumor cells and environmental factors. However, current knowledge concerning resistance mechanisms cannot completely explain the phenomenon of multi-drug resistance, which occurs in the vast majority of patients treated with chemotherapy. In this opinion article, we investigate the role of these factors in the development of drug-resistance.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.10992.1