Microglia and Their Promising Role in Ischemic Brain Injuries: An Update

Ischemic brain injuries are common diseases with high morbidity, disability, and mortality rates, which have significant impacts on human health and life. Microglia are resident cells of the central nervous system. The inflammatory responses mediated by microglia play an important role in the occurr...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2020-07, Vol.14, p.211-211
Main Authors: Yu, Luting, Su, Xiaojuan, Li, Shiping, Zhao, Fengyan, Mu, Dezhi, Qu, Yi
Format: Article
Language:English
Subjects:
Antigens
Brain damage
Brain injury
Cellular Neuroscience
Central nervous system
Cytokines
depletion
Genotype & phenotype
Inflammation
Ischemia
ischemic brain injuries
Medical prognosis
Microglia
Morbidity
Pathogenesis
polarization
repopulation
Traumatic brain injury
Tumor necrosis factor-TNF
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Summary:Ischemic brain injuries are common diseases with high morbidity, disability, and mortality rates, which have significant impacts on human health and life. Microglia are resident cells of the central nervous system. The inflammatory responses mediated by microglia play an important role in the occurrence and development of ischemic brain injuries. This article summarizes the activation, polarization, depletion, and repopulation of microglia after ischemic brain injuries, proposing new treatment strategies for such injuries through the modulation of microglia function.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2020.00211