CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72

NK cells are able to kill tumor and virus-infected cells without the need of prior antigen stimulation. The killing of these target cells is regulated by inhibitory, lysis and co-stimulatory receptors that are expressed on the surface of NK cells. CD100 (Semaphorin 4D), a 150kD transmembrane protein...

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Bibliographic Details
Published in:PloS one 2007-09, Vol.2 (9), p.e818-e818
Main Authors: Mizrahi, Sa'ar, Markel, Gal, Porgador, Angel, Bushkin, Yuri, Mandelboim, Ofer
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antigens, CD - immunology
Antigens, Differentiation, B-Lymphocyte - immunology
Cell Adhesion
Cell Line
Cytotoxicity, Immunologic
Humans
Interferon-gamma - secretion
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Killer Cells, Natural - secretion
Ligands
Lymphocyte Activation - immunology
Mice
Molecular Weight
Phosphoserine - metabolism
Protein Binding
Protein Multimerization
Semaphorins - immunology
Up-Regulation - genetics
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Summary:NK cells are able to kill tumor and virus-infected cells without the need of prior antigen stimulation. The killing of these target cells is regulated by inhibitory, lysis and co-stimulatory receptors that are expressed on the surface of NK cells. CD100 (Semaphorin 4D), a 150kD transmembrane protein, is expressed on the surface of activated NK cells as a homodimer, mediates the killing of target cells by binding to CD72. CD100 is not involved directly in the killing process but is rather increases NK cytotoxicity by enhancing the adhesion between NK cells and their targets. This increased adhesion leads to a more efficient killing and enhanced IFNgamma secretion. Since CD72 is expressed on antigen presenting cells (APC) and the CD100-CD72 interaction lead to the shading of CD100, we suggest that NK interacting with APC cells could be the early source of soluble CD100 which is crucial for the formation of antigen specific immune response. CD100-CD72 interaction can be the mechanism by which NK cell communicate with B cells.
ISSN:1932-6203
DOI:10.1371/journal.pone.0000818