Human CARD9: A Critical Molecule of Fungal Immune Surveillance

CARD9 is a signaling adaptor protein that is involved in the transduction of signals from a variety of innate pattern recognition receptors, including the C-type lectin receptors and intracellular NOD receptors and nucleic acid sensors. As a result, CARD9 has been shown in animal models to be an imp...

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Bibliographic Details
Published in:Frontiers in immunology 2018-08, Vol.9, p.1836-1836
Main Authors: Drummond, Rebecca A, Franco, Luis M, Lionakis, Michail S
Format: Article
Language:English
Subjects:
C-type lectin receptors
candidiasis
CARD9
fungi
Immunology
neutrophils
primary immunodeficiency
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Summary:CARD9 is a signaling adaptor protein that is involved in the transduction of signals from a variety of innate pattern recognition receptors, including the C-type lectin receptors and intracellular NOD receptors and nucleic acid sensors. As a result, CARD9 has been shown in animal models to be an important regulator of immunity to bacteria, fungi, and viruses. Studies in humans with autosomal recessive CARD9 deficiency have indicated a highly specific role for this molecule in the activation of antifungal immune responses in the central nervous system, the oral mucosa, and the skin. Moreover, CARD9-dependent functions have recently been indicated to modulate the development of autoimmunity, inflammatory bowel diseases, and cancer. In this mini-review, we highlight the recent studies that have identified several novel functions of CARD9 in various disease contexts, and we summarize the contemporary understanding of the genetics and immunology of human CARD9 deficiency.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.01836