Uric Acid Levels in Patients on Antituberculosis Drugs in the Southwest Region of Cameroon

Abstract Objective/Background Antituberculosis drugs (ATDs) efficiently combat Mycobacterium tuberculosis either through direct molecular interactions or those of its metabolites. However, a variety of adverse effects have been reported, leading to frequent interruptions of treatment. In order to in...

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Bibliographic Details
Published in:International journal of mycobacteriology 2016-12, Vol.5 (5), p.S116-S116
Main Authors: D.T. Pokam, Benjamin, Eeteneneng, Enoh J, Umoh, Aniekan, Umoh, N.O, Guemdjom, P.W
Format: Article
Language:English
Subjects:
Antitubercular agents
Antituberculosis drugs
Cameroon
Care and treatment
Hyperuricemia
Infectious Disease
Intensive phase
Medical Education
South west region
Tuberculosis
Uric acid
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Summary:Abstract Objective/Background Antituberculosis drugs (ATDs) efficiently combat Mycobacterium tuberculosis either through direct molecular interactions or those of its metabolites. However, a variety of adverse effects have been reported, leading to frequent interruptions of treatment. In order to investigate possible metabolic disturbances resulting from antituberculosis treatment, the uric acid level of patients on ATDs was measured in the Southwest region of Cameroon. Methods This hospital-based cross-sectional study involved 96 tuberculosis patients on ATDs and 32 controls who were neither on ATDs nor any other treatment that could increase uric acid levels. The hospital records of consenting participants were reviewed for medical history and questionnaires were issued. About 2-mL venous blood was collected and analyzed using spectrophotometers to determine uric acid levels. Results Hyperuricemia was observed in 56/96 (58.3%) of the studied group as compared with four of 32 (12.5%) in the control group ( p < .001). Our results indicated that treatment duration was significantly associated with hyperuricemia ( p = .0016), while gender ( p = .1275) was not. Conclusion Hyperuricemia is associated with ATDs, with treatment duration being a significant factor. The disorder should be closely monitored, especially during the intensive phase of treatment.
ISSN:2212-5531
2212-554X
DOI:10.1016/j.ijmyco.2016.09.058