Loading…
Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA
We determined estimated incidence of and risk factors for community-associated Clostridium difficile infection (CA-CDI) among patients treated at 6 North Carolina hospitals. CA-CDI case-patients were defined as adults (>18 years of age) with a positive stool test result for C. difficile toxin and...
Saved in:
| Published in: | Emerging infectious diseases 2010-02, Vol.16 (2), p.197-204 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 204 |
| container_issue | 2 |
| container_start_page | 197 |
| container_title | Emerging infectious diseases |
| container_volume | 16 |
| creator | KUTTY, P.K WOODS, C.W SENA, A.C BENOIT, S.T NAGGIE, S FREDERICK, J EVANS, S ENGEL, J MCDONALD, L.C |
| description | We determined estimated incidence of and risk factors for community-associated Clostridium difficile infection (CA-CDI) among patients treated at 6 North Carolina hospitals. CA-CDI case-patients were defined as adults (>18 years of age) with a positive stool test result for C. difficile toxin and no hospitalization within the prior 8 weeks. CA-CDI incidence was 21 and 46 per 100,000 person-years in Veterans Affairs (VA) outpatients and Durham County populations, respectively. VA case-patients were more likely than controls to have received antimicrobial drugs (adjusted odds ratio [aOR] 17.8, 95% confidence interval [CI] 6.6-48] and to have had a recent outpatient visit (aOR 5.1, 95% CI 1.5-17.9). County case-patients were more likely than controls to have received antimicrobial drugs (aOR 9.1, 95% CI 2.9-28.9), to have gastroesophageal reflux disease (aOR 11.2, 95% CI 1.9-64.2), and to have cardiac failure (aOR 3.8, 95% CI 1.1-13.7). Risk factors for CA-CDI overlap with those for healthcare-associated infection. |
| doi_str_mv | 10.3201/eid1602.090953 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_c7c96470b01e47e3865a7507d3d78fcb</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A221918643</galeid><doaj_id>oai_doaj_org_article_c7c96470b01e47e3865a7507d3d78fcb</doaj_id><sourcerecordid>A221918643</sourcerecordid><originalsourceid>FETCH-LOGICAL-d510t-ab3963e7c4d1c016614154cde72dae57efda0985a8168866af3900a0acb995f3</originalsourceid><addsrcrecordid>eNqN0s9rFDEUB_BBFFurV48SEBWhsyaTmWRyXBZ_LBQLbfU6vE1edlNnJjXJgP3vTbtrdWEPksML4fMe5JsUxUtGZ7yi7AM6wwStZlRR1fBHxTGjLS0FbdTjh31Nj4pnMV5TynKLeloc5cJ4U8vjYrpw8QexoJMPkVgfCIyGYExugISGuFE7g6NG4i3Rfhim0aXbEmL02t2LRe9jCs64aSDGWeu06zH3WdTJ-fGUfPUhbcgCgu_dCKfk2-X8efHEQh_xxa6eFFefPl4tvpRn55-Xi_lZaRpGUwkrrgRHqWvDNGVCsJo1tTYoKwPYSLQGqGobaJloWyHAckUpUNArpRrLT4rldqzxcN3dhHyncNt5cN39gQ_rDkJyusdOS61ELemKMqwl8lY0IBsqDTeytXqVZ73bzroJ_ueUA-oGFzX2PYzop9hJzjmtqqbK8vVWriEPzkH4FEDf6W5eVUyxVtQ8q_KAWuOIAXo_os0p7vvZAZ-XwcHpgw3v9xqySfgrrWGKsVteXvy_Pf--b9_-YzcIfdpE3093jx334atdYtNqQPOQ_5_Pl8GbHYCoobcB8meLfx1vKa9rxX8D0Rfj8w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733302252</pqid></control><display><type>article</type><title>Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA</title><source>PubMed Central</source><creator>KUTTY, P.K ; WOODS, C.W ; SENA, A.C ; BENOIT, S.T ; NAGGIE, S ; FREDERICK, J ; EVANS, S ; ENGEL, J ; MCDONALD, L.C</creator><creatorcontrib>KUTTY, P.K ; WOODS, C.W ; SENA, A.C ; BENOIT, S.T ; NAGGIE, S ; FREDERICK, J ; EVANS, S ; ENGEL, J ; MCDONALD, L.C</creatorcontrib><description>We determined estimated incidence of and risk factors for community-associated Clostridium difficile infection (CA-CDI) among patients treated at 6 North Carolina hospitals. CA-CDI case-patients were defined as adults (>18 years of age) with a positive stool test result for C. difficile toxin and no hospitalization within the prior 8 weeks. CA-CDI incidence was 21 and 46 per 100,000 person-years in Veterans Affairs (VA) outpatients and Durham County populations, respectively. VA case-patients were more likely than controls to have received antimicrobial drugs (adjusted odds ratio [aOR] 17.8, 95% confidence interval [CI] 6.6-48] and to have had a recent outpatient visit (aOR 5.1, 95% CI 1.5-17.9). County case-patients were more likely than controls to have received antimicrobial drugs (aOR 9.1, 95% CI 2.9-28.9), to have gastroesophageal reflux disease (aOR 11.2, 95% CI 1.9-64.2), and to have cardiac failure (aOR 3.8, 95% CI 1.1-13.7). Risk factors for CA-CDI overlap with those for healthcare-associated infection.</description><identifier>ISSN: 1080-6040</identifier><identifier>EISSN: 1080-6059</identifier><identifier>DOI: 10.3201/eid1602.090953</identifier><identifier>PMID: 20113547</identifier><language>eng</language><publisher>United States: U.S. National Center for Infectious Diseases</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Anti-infective agents ; bacteria ; Bacterial Proteins - analysis ; Bacterial Toxins - analysis ; Biological and medical sciences ; Case-Control Studies ; Clostridium difficile ; Clostridium Infections - epidemiology ; community ; Community-Acquired Infections - epidemiology ; Dysentery - epidemiology ; enteric infections ; Enterotoxins - analysis ; Feces - chemistry ; Female ; Health aspects ; Heart failure ; Humans ; Incidence ; Infection ; Male ; Medical research ; Medical sciences ; Medicine, Experimental ; Middle Aged ; Miscellaneous ; North Carolina - epidemiology ; Odds Ratio ; Prejudice ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Veterans ; Young Adult</subject><ispartof>Emerging infectious diseases, 2010-02, Vol.16 (2), p.197-204</ispartof><rights>COPYRIGHT 2010 U.S. National Center for Infectious Diseases</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23803449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20113547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUTTY, P.K</creatorcontrib><creatorcontrib>WOODS, C.W</creatorcontrib><creatorcontrib>SENA, A.C</creatorcontrib><creatorcontrib>BENOIT, S.T</creatorcontrib><creatorcontrib>NAGGIE, S</creatorcontrib><creatorcontrib>FREDERICK, J</creatorcontrib><creatorcontrib>EVANS, S</creatorcontrib><creatorcontrib>ENGEL, J</creatorcontrib><creatorcontrib>MCDONALD, L.C</creatorcontrib><title>Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA</title><title>Emerging infectious diseases</title><addtitle>Emerg Infect Dis</addtitle><description>We determined estimated incidence of and risk factors for community-associated Clostridium difficile infection (CA-CDI) among patients treated at 6 North Carolina hospitals. CA-CDI case-patients were defined as adults (>18 years of age) with a positive stool test result for C. difficile toxin and no hospitalization within the prior 8 weeks. CA-CDI incidence was 21 and 46 per 100,000 person-years in Veterans Affairs (VA) outpatients and Durham County populations, respectively. VA case-patients were more likely than controls to have received antimicrobial drugs (adjusted odds ratio [aOR] 17.8, 95% confidence interval [CI] 6.6-48] and to have had a recent outpatient visit (aOR 5.1, 95% CI 1.5-17.9). County case-patients were more likely than controls to have received antimicrobial drugs (aOR 9.1, 95% CI 2.9-28.9), to have gastroesophageal reflux disease (aOR 11.2, 95% CI 1.9-64.2), and to have cardiac failure (aOR 3.8, 95% CI 1.1-13.7). Risk factors for CA-CDI overlap with those for healthcare-associated infection.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-infective agents</subject><subject>bacteria</subject><subject>Bacterial Proteins - analysis</subject><subject>Bacterial Toxins - analysis</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Clostridium difficile</subject><subject>Clostridium Infections - epidemiology</subject><subject>community</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Dysentery - epidemiology</subject><subject>enteric infections</subject><subject>Enterotoxins - analysis</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Health aspects</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infection</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>North Carolina - epidemiology</subject><subject>Odds Ratio</subject><subject>Prejudice</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Veterans</subject><subject>Young Adult</subject><issn>1080-6040</issn><issn>1080-6059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqN0s9rFDEUB_BBFFurV48SEBWhsyaTmWRyXBZ_LBQLbfU6vE1edlNnJjXJgP3vTbtrdWEPksML4fMe5JsUxUtGZ7yi7AM6wwStZlRR1fBHxTGjLS0FbdTjh31Nj4pnMV5TynKLeloc5cJ4U8vjYrpw8QexoJMPkVgfCIyGYExugISGuFE7g6NG4i3Rfhim0aXbEmL02t2LRe9jCs64aSDGWeu06zH3WdTJ-fGUfPUhbcgCgu_dCKfk2-X8efHEQh_xxa6eFFefPl4tvpRn55-Xi_lZaRpGUwkrrgRHqWvDNGVCsJo1tTYoKwPYSLQGqGobaJloWyHAckUpUNArpRrLT4rldqzxcN3dhHyncNt5cN39gQ_rDkJyusdOS61ELemKMqwl8lY0IBsqDTeytXqVZ73bzroJ_ueUA-oGFzX2PYzop9hJzjmtqqbK8vVWriEPzkH4FEDf6W5eVUyxVtQ8q_KAWuOIAXo_os0p7vvZAZ-XwcHpgw3v9xqySfgrrWGKsVteXvy_Pf--b9_-YzcIfdpE3093jx334atdYtNqQPOQ_5_Pl8GbHYCoobcB8meLfx1vKa9rxX8D0Rfj8w</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>KUTTY, P.K</creator><creator>WOODS, C.W</creator><creator>SENA, A.C</creator><creator>BENOIT, S.T</creator><creator>NAGGIE, S</creator><creator>FREDERICK, J</creator><creator>EVANS, S</creator><creator>ENGEL, J</creator><creator>MCDONALD, L.C</creator><general>U.S. National Center for Infectious Diseases</general><general>Centers for Disease Control and Prevention</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>IOV</scope><scope>ISR</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20100201</creationdate><title>Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA</title><author>KUTTY, P.K ; WOODS, C.W ; SENA, A.C ; BENOIT, S.T ; NAGGIE, S ; FREDERICK, J ; EVANS, S ; ENGEL, J ; MCDONALD, L.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d510t-ab3963e7c4d1c016614154cde72dae57efda0985a8168866af3900a0acb995f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-infective agents</topic><topic>bacteria</topic><topic>Bacterial Proteins - analysis</topic><topic>Bacterial Toxins - analysis</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Clostridium difficile</topic><topic>Clostridium Infections - epidemiology</topic><topic>community</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Dysentery - epidemiology</topic><topic>enteric infections</topic><topic>Enterotoxins - analysis</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Health aspects</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infection</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>North Carolina - epidemiology</topic><topic>Odds Ratio</topic><topic>Prejudice</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Veterans</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUTTY, P.K</creatorcontrib><creatorcontrib>WOODS, C.W</creatorcontrib><creatorcontrib>SENA, A.C</creatorcontrib><creatorcontrib>BENOIT, S.T</creatorcontrib><creatorcontrib>NAGGIE, S</creatorcontrib><creatorcontrib>FREDERICK, J</creatorcontrib><creatorcontrib>EVANS, S</creatorcontrib><creatorcontrib>ENGEL, J</creatorcontrib><creatorcontrib>MCDONALD, L.C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>DOAJ</collection><jtitle>Emerging infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUTTY, P.K</au><au>WOODS, C.W</au><au>SENA, A.C</au><au>BENOIT, S.T</au><au>NAGGIE, S</au><au>FREDERICK, J</au><au>EVANS, S</au><au>ENGEL, J</au><au>MCDONALD, L.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA</atitle><jtitle>Emerging infectious diseases</jtitle><addtitle>Emerg Infect Dis</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>16</volume><issue>2</issue><spage>197</spage><epage>204</epage><pages>197-204</pages><issn>1080-6040</issn><eissn>1080-6059</eissn><abstract>We determined estimated incidence of and risk factors for community-associated Clostridium difficile infection (CA-CDI) among patients treated at 6 North Carolina hospitals. CA-CDI case-patients were defined as adults (>18 years of age) with a positive stool test result for C. difficile toxin and no hospitalization within the prior 8 weeks. CA-CDI incidence was 21 and 46 per 100,000 person-years in Veterans Affairs (VA) outpatients and Durham County populations, respectively. VA case-patients were more likely than controls to have received antimicrobial drugs (adjusted odds ratio [aOR] 17.8, 95% confidence interval [CI] 6.6-48] and to have had a recent outpatient visit (aOR 5.1, 95% CI 1.5-17.9). County case-patients were more likely than controls to have received antimicrobial drugs (aOR 9.1, 95% CI 2.9-28.9), to have gastroesophageal reflux disease (aOR 11.2, 95% CI 1.9-64.2), and to have cardiac failure (aOR 3.8, 95% CI 1.1-13.7). Risk factors for CA-CDI overlap with those for healthcare-associated infection.</abstract><cop>United States</cop><pub>U.S. National Center for Infectious Diseases</pub><pmid>20113547</pmid><doi>10.3201/eid1602.090953</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1080-6040 |
| ispartof | Emerging infectious diseases, 2010-02, Vol.16 (2), p.197-204 |
| issn | 1080-6040 1080-6059 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_c7c96470b01e47e3865a7507d3d78fcb |
| source | PubMed Central |
| subjects | Adult Age Distribution Aged Aged, 80 and over Anti-infective agents bacteria Bacterial Proteins - analysis Bacterial Toxins - analysis Biological and medical sciences Case-Control Studies Clostridium difficile Clostridium Infections - epidemiology community Community-Acquired Infections - epidemiology Dysentery - epidemiology enteric infections Enterotoxins - analysis Feces - chemistry Female Health aspects Heart failure Humans Incidence Infection Male Medical research Medical sciences Medicine, Experimental Middle Aged Miscellaneous North Carolina - epidemiology Odds Ratio Prejudice Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Veterans Young Adult |
| title | Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A52%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20factors%20for%20and%20estimated%20incidence%20of%20community-associated%20Clostridium%20difficile%20infection,%20North%20Carolina,%20USA&rft.jtitle=Emerging%20infectious%20diseases&rft.au=KUTTY,%20P.K&rft.date=2010-02-01&rft.volume=16&rft.issue=2&rft.spage=197&rft.epage=204&rft.pages=197-204&rft.issn=1080-6040&rft.eissn=1080-6059&rft_id=info:doi/10.3201/eid1602.090953&rft_dat=%3Cgale_doaj_%3EA221918643%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-d510t-ab3963e7c4d1c016614154cde72dae57efda0985a8168866af3900a0acb995f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=733302252&rft_id=info:pmid/20113547&rft_galeid=A221918643&rfr_iscdi=true |