A prospective, comparative analysis of acute toxicity profile between three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) in locally advanced head and neck cancer patients

•Radiotherapy is an important treatment modality in the management of head and neck carcinoma.•The advances of modern radiotherapy techniques have emerged with the development of conformal radiotherapy techniques, such as the three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated r...

Full description

Saved in:
Bibliographic Details
Published in:Cancer treatment and research communications 2020, Vol.25, p.100223-100223, Article 100223
Main Authors: Kucha, Nilesh, Soni, Tej Prakash, Jakhotia, Naresh, Patni, Nidhi, Singh, Dinesh Kumar, Gupta, Anil Kumar, Sharma, Lalit Mohan, Goyal, Jaishree
Format: Article
Language:English
Subjects:
Compliance
Conformal radiotherapy
Head neck cancer
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Radiotherapy is an important treatment modality in the management of head and neck carcinoma.•The advances of modern radiotherapy techniques have emerged with the development of conformal radiotherapy techniques, such as the three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT).•We prospectively compared acute toxicities and compliance to the treatment between IMRT and 3DCRT in patients with locally advanced head and neck carcinoma.•IMRT reduced the chemo-radiotherapy induced severe acute mucositis, dysphagia, xerostomia and nasogastric tube feeding requirement and it improved the treatment-compliance compared to 3DCRT in locally advanced head neck cancer patients. The advances of modern radiotherapy have emerged with the development of conformal radiotherapy techniques, such as the three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT). We prospectively compared acute toxicities and treatment-compliance between IMRT and 3DCRT in patients with locally advanced head and neck carcinoma. 80 patients were enrolled in this comparative prospective non-randomized study. Inclusion criteria were patients with locally advanced carcinoma of hypopharynx, oropharynx and larynx. 40 patients were treated with IMRT and 40 patients with 3DCRT to dose of 70 Gy in 35 fractions, along with concurrent cisplatin weekly chemotherapy. All patients were assessed weekly during chemoradiotherapy treatment and after 3 months of the treatment. 15 patients (38.4%) versus 8 patients (20.51%) developed grade 3 mucositis in the 3DCRT and IMRT group respectively (p=
ISSN:2468-2942
2468-2942
DOI:10.1016/j.ctarc.2020.100223