Loading…
Five Unreported Ketone Compounds-Penicrustones A-E-From the Endophytic Fungus Penicillium crustosum
Five unreported ketone compounds-penicrustones A-E-were isolated from the solid fermentation of the endophytic fungus . Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray cryst...
Saved in:
| Published in: | Microorganisms (Basel) 2024-10, Vol.12 (11), p.2195 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c425t-4605e5251542110d4bcfbe2c5ef357906b824175b415c551de329bbf40ea99c73 |
| container_end_page | |
| container_issue | 11 |
| container_start_page | 2195 |
| container_title | Microorganisms (Basel) |
| container_volume | 12 |
| creator | Lin, Dongmei Yang, Lian Yang, Jin Li, Feixing Cui, Xiuming Yang, Xiaoyan |
| description | Five unreported ketone compounds-penicrustones A-E-were isolated from the solid fermentation of the endophytic fungus
. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography. All compounds were evaluated for their antimicrobial and antitumor activities. Compounds
and
showed moderate inhibitory effects on
, with MIC values of 12.5 and 25.0 μg/mL, respectively. In addition to this, compound 4 also showed cytotoxicity on tumor cell lines KTC-1 and Hela, with IC
values of 4.28 and 4.64 μg/mL, respectively. |
| doi_str_mv | 10.3390/microorganisms12112195 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_c7e1be5405044a40a3daf285cd8319b3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A818336278</galeid><doaj_id>oai_doaj_org_article_c7e1be5405044a40a3daf285cd8319b3</doaj_id><sourcerecordid>A818336278</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-4605e5251542110d4bcfbe2c5ef357906b824175b415c551de329bbf40ea99c73</originalsourceid><addsrcrecordid>eNptUk1r3DAQNaWlCWn-QjD00otTfY1tncqy7LahgfbQnIUsj3e12NJWsgL591XWaUhKJYHE6L03M9IriitKrjmX5PNkTfA-7LSzcYqU0bwkvCnOGWnqitWkefvifFZcxnggeUjKW6DvizMuQTbQivPCbO09lncu4NGHGfvyO87eYbn209En18fqJ7qcLsXHcCxX1abaBj-V8x7Ljev9cf8wW1Nuk9ulWJ7AdhxtmsqFFNP0oXg36DHi5dN-UdxtN7_W36rbH19v1qvbyggGcyVqAggMKIjcEelFZ4YOmQEcODSS1F3LBG2gExQMAO2RM9l1gyCopTQNvyhuFt3e64M6Bjvp8KC8tuoUyA-mdMjFjqhMg7RDEASIEFoQzXs9sBZM33IqO561vixax9RN2Bt0c9DjK9HXN87u1c7fK0pB1rmBrPDpSSH43wnjrCYbDY6jduhTVJxyLqBlBDL04z_Qg0_B5bc6obhgktYZdb2gdjp3YN3gc2KTZ4_ZEPl3Bpvjq5a2nNesaTOhXgjZLTEGHJ7Lp0Q9Gkn930iZePWy-WfaX9vwP8V1yKw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3133342916</pqid></control><display><type>article</type><title>Five Unreported Ketone Compounds-Penicrustones A-E-From the Endophytic Fungus Penicillium crustosum</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Lin, Dongmei ; Yang, Lian ; Yang, Jin ; Li, Feixing ; Cui, Xiuming ; Yang, Xiaoyan</creator><creatorcontrib>Lin, Dongmei ; Yang, Lian ; Yang, Jin ; Li, Feixing ; Cui, Xiuming ; Yang, Xiaoyan</creatorcontrib><description>Five unreported ketone compounds-penicrustones A-E-were isolated from the solid fermentation of the endophytic fungus
. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography. All compounds were evaluated for their antimicrobial and antitumor activities. Compounds
and
showed moderate inhibitory effects on
, with MIC values of 12.5 and 25.0 μg/mL, respectively. In addition to this, compound 4 also showed cytotoxicity on tumor cell lines KTC-1 and Hela, with IC
values of 4.28 and 4.64 μg/mL, respectively.</description><identifier>ISSN: 2076-2607</identifier><identifier>EISSN: 2076-2607</identifier><identifier>DOI: 10.3390/microorganisms12112195</identifier><identifier>PMID: 39597584</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>activity ; Analysis ; Antimicrobial agents ; Antitumor activity ; Antitumor agents ; Cancer ; Chromatography ; Crystallography ; Cytotoxicity ; Endophytes ; Fermentation ; Fungi ; fungus ; Ketones ; Metabolites ; NMR ; Nuclear magnetic resonance ; Penicillium crustosum ; penicrustone ; Seeds ; Single crystals ; Tumor cell lines ; X-ray crystallography ; X-Ray diffraction ; Yang Lian</subject><ispartof>Microorganisms (Basel), 2024-10, Vol.12 (11), p.2195</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c425t-4605e5251542110d4bcfbe2c5ef357906b824175b415c551de329bbf40ea99c73</cites><orcidid>0000-0002-0691-0406</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3133342916/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3133342916?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39597584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Dongmei</creatorcontrib><creatorcontrib>Yang, Lian</creatorcontrib><creatorcontrib>Yang, Jin</creatorcontrib><creatorcontrib>Li, Feixing</creatorcontrib><creatorcontrib>Cui, Xiuming</creatorcontrib><creatorcontrib>Yang, Xiaoyan</creatorcontrib><title>Five Unreported Ketone Compounds-Penicrustones A-E-From the Endophytic Fungus Penicillium crustosum</title><title>Microorganisms (Basel)</title><addtitle>Microorganisms</addtitle><description>Five unreported ketone compounds-penicrustones A-E-were isolated from the solid fermentation of the endophytic fungus
. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography. All compounds were evaluated for their antimicrobial and antitumor activities. Compounds
and
showed moderate inhibitory effects on
, with MIC values of 12.5 and 25.0 μg/mL, respectively. In addition to this, compound 4 also showed cytotoxicity on tumor cell lines KTC-1 and Hela, with IC
values of 4.28 and 4.64 μg/mL, respectively.</description><subject>activity</subject><subject>Analysis</subject><subject>Antimicrobial agents</subject><subject>Antitumor activity</subject><subject>Antitumor agents</subject><subject>Cancer</subject><subject>Chromatography</subject><subject>Crystallography</subject><subject>Cytotoxicity</subject><subject>Endophytes</subject><subject>Fermentation</subject><subject>Fungi</subject><subject>fungus</subject><subject>Ketones</subject><subject>Metabolites</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Penicillium crustosum</subject><subject>penicrustone</subject><subject>Seeds</subject><subject>Single crystals</subject><subject>Tumor cell lines</subject><subject>X-ray crystallography</subject><subject>X-Ray diffraction</subject><subject>Yang Lian</subject><issn>2076-2607</issn><issn>2076-2607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1r3DAQNaWlCWn-QjD00otTfY1tncqy7LahgfbQnIUsj3e12NJWsgL591XWaUhKJYHE6L03M9IriitKrjmX5PNkTfA-7LSzcYqU0bwkvCnOGWnqitWkefvifFZcxnggeUjKW6DvizMuQTbQivPCbO09lncu4NGHGfvyO87eYbn209En18fqJ7qcLsXHcCxX1abaBj-V8x7Ljev9cf8wW1Nuk9ulWJ7AdhxtmsqFFNP0oXg36DHi5dN-UdxtN7_W36rbH19v1qvbyggGcyVqAggMKIjcEelFZ4YOmQEcODSS1F3LBG2gExQMAO2RM9l1gyCopTQNvyhuFt3e64M6Bjvp8KC8tuoUyA-mdMjFjqhMg7RDEASIEFoQzXs9sBZM33IqO561vixax9RN2Bt0c9DjK9HXN87u1c7fK0pB1rmBrPDpSSH43wnjrCYbDY6jduhTVJxyLqBlBDL04z_Qg0_B5bc6obhgktYZdb2gdjp3YN3gc2KTZ4_ZEPl3Bpvjq5a2nNesaTOhXgjZLTEGHJ7Lp0Q9Gkn930iZePWy-WfaX9vwP8V1yKw</recordid><startdate>20241030</startdate><enddate>20241030</enddate><creator>Lin, Dongmei</creator><creator>Yang, Lian</creator><creator>Yang, Jin</creator><creator>Li, Feixing</creator><creator>Cui, Xiuming</creator><creator>Yang, Xiaoyan</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0691-0406</orcidid></search><sort><creationdate>20241030</creationdate><title>Five Unreported Ketone Compounds-Penicrustones A-E-From the Endophytic Fungus Penicillium crustosum</title><author>Lin, Dongmei ; Yang, Lian ; Yang, Jin ; Li, Feixing ; Cui, Xiuming ; Yang, Xiaoyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-4605e5251542110d4bcfbe2c5ef357906b824175b415c551de329bbf40ea99c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>activity</topic><topic>Analysis</topic><topic>Antimicrobial agents</topic><topic>Antitumor activity</topic><topic>Antitumor agents</topic><topic>Cancer</topic><topic>Chromatography</topic><topic>Crystallography</topic><topic>Cytotoxicity</topic><topic>Endophytes</topic><topic>Fermentation</topic><topic>Fungi</topic><topic>fungus</topic><topic>Ketones</topic><topic>Metabolites</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Penicillium crustosum</topic><topic>penicrustone</topic><topic>Seeds</topic><topic>Single crystals</topic><topic>Tumor cell lines</topic><topic>X-ray crystallography</topic><topic>X-Ray diffraction</topic><topic>Yang Lian</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Dongmei</creatorcontrib><creatorcontrib>Yang, Lian</creatorcontrib><creatorcontrib>Yang, Jin</creatorcontrib><creatorcontrib>Li, Feixing</creatorcontrib><creatorcontrib>Cui, Xiuming</creatorcontrib><creatorcontrib>Yang, Xiaoyan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Biological Sciences</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Microorganisms (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Dongmei</au><au>Yang, Lian</au><au>Yang, Jin</au><au>Li, Feixing</au><au>Cui, Xiuming</au><au>Yang, Xiaoyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Five Unreported Ketone Compounds-Penicrustones A-E-From the Endophytic Fungus Penicillium crustosum</atitle><jtitle>Microorganisms (Basel)</jtitle><addtitle>Microorganisms</addtitle><date>2024-10-30</date><risdate>2024</risdate><volume>12</volume><issue>11</issue><spage>2195</spage><pages>2195-</pages><issn>2076-2607</issn><eissn>2076-2607</eissn><abstract>Five unreported ketone compounds-penicrustones A-E-were isolated from the solid fermentation of the endophytic fungus
. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography. All compounds were evaluated for their antimicrobial and antitumor activities. Compounds
and
showed moderate inhibitory effects on
, with MIC values of 12.5 and 25.0 μg/mL, respectively. In addition to this, compound 4 also showed cytotoxicity on tumor cell lines KTC-1 and Hela, with IC
values of 4.28 and 4.64 μg/mL, respectively.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39597584</pmid><doi>10.3390/microorganisms12112195</doi><orcidid>https://orcid.org/0000-0002-0691-0406</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2076-2607 |
| ispartof | Microorganisms (Basel), 2024-10, Vol.12 (11), p.2195 |
| issn | 2076-2607 2076-2607 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_c7e1be5405044a40a3daf285cd8319b3 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | activity Analysis Antimicrobial agents Antitumor activity Antitumor agents Cancer Chromatography Crystallography Cytotoxicity Endophytes Fermentation Fungi fungus Ketones Metabolites NMR Nuclear magnetic resonance Penicillium crustosum penicrustone Seeds Single crystals Tumor cell lines X-ray crystallography X-Ray diffraction Yang Lian |
| title | Five Unreported Ketone Compounds-Penicrustones A-E-From the Endophytic Fungus Penicillium crustosum |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T21%3A08%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Five%20Unreported%20Ketone%20Compounds-Penicrustones%20A-E-From%20the%20Endophytic%20Fungus%20Penicillium%20crustosum&rft.jtitle=Microorganisms%20(Basel)&rft.au=Lin,%20Dongmei&rft.date=2024-10-30&rft.volume=12&rft.issue=11&rft.spage=2195&rft.pages=2195-&rft.issn=2076-2607&rft.eissn=2076-2607&rft_id=info:doi/10.3390/microorganisms12112195&rft_dat=%3Cgale_doaj_%3EA818336278%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c425t-4605e5251542110d4bcfbe2c5ef357906b824175b415c551de329bbf40ea99c73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3133342916&rft_id=info:pmid/39597584&rft_galeid=A818336278&rfr_iscdi=true |