Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiologic...

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Bibliographic Details
Published in:Molecular medicine (Cambridge, Mass.) Mass.), 2023-10, Vol.29 (1), p.136-136, Article 136
Main Authors: Liu, Meijin, Lai, Zhonghong, Yuan, Xiaoying, Jin, Qing, Shen, Haibin, Rao, Dingyu, Huang, Defa
Format: Article
Language:English
Subjects:
Cellular drug resistance
Diagnosis
Exosomes
Hepatocellular carcinoma
Migration and transfer
Proliferation
Review
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Summary:Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiological and pathological conditions, which play an important role in the biological information transfer between cells. There is growing evidence that HCC cell-derived exosomes may contribute to the establishment of a favorable microenvironment that supports cancer cell proliferation, invasion, and metastasis. These exosomes not only provide a versatile platform for diagnosis but also serve as a vehicle for drug delivery. In this paper, we review the role of exosomes involved in the proliferation, migration, and metastasis of HCC and describe their application in HCC diagnosis and treatment. We also discuss the prospects of exosome application in HCC and the research challenges.
ISSN:1528-3658
1076-1551
1528-3658
DOI:10.1186/s10020-023-00731-5