MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia

Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on...

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Bibliographic Details
Published in:Mediators of Inflammation 2016-01, Vol.2016 (2016), p.155-163-014
Main Authors: Chen, Ning, Yang, Yi, Kou, Xianjuan, Fan, Jingjing
Format: Article
Language:English
Subjects:
Aging
Animals
Autophagy
C-Reactive Protein - metabolism
Cytokines
Exercise
Gene expression
Health promotion
Humans
Inflammation
Inflammation - genetics
Inflammation - immunology
Inflammation - metabolism
Insulin resistance
Interleukin-6 - metabolism
Interleukins
Metabolism
MicroRNA
MicroRNAs - genetics
MicroRNAs - metabolism
Mitochondria
Muscles
Musculoskeletal system
Obesity
Oxidative stress
Pathogenesis
Physical fitness
Protein synthesis
Proteins
Regulation
Review
Rodents
Sarcopenia
Sarcopenia - genetics
Sarcopenia - immunology
Sarcopenia - metabolism
Transcription factors
Tumor necrosis factor
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
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Summary:Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on sarcopenia. Several proinflammatory cytokines, especially interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), play crucial roles in modulation of inflammatory signaling pathway during the aging-related loss of skeletal muscle. MicroRNAs (miRNAs) have emerged as the important regulators for the mass and functional maintenance of skeletal muscle through regulating gene expression of proinflammatory cytokines. In this paper, we have systematically discussed regulatory mechanisms of miRNAs for the expression and secretion of inflammatory cytokines during sarcopenia, which will provide some novel targets and therapeutic strategies for controlling aging-related atrophy of skeletal muscle and corresponding chronic inflammatory diseases.
ISSN:0962-9351
1466-1861
DOI:10.1155/2016/1438686