Nelsonia canescens (Acanthaceae) aqueous extract and partitioned fractions ameliorates type-2 diabetes in alloxan-induced diabetic rats

Background Diabetes mellitus is a metabolic disorder that affects the body’s ability to produce or use insulin. There is a continuous rise of this disease particularly in developing countries due to changes in life style and poverty among the people. In this study, antidiabetic activities of aqueous...

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Bibliographic Details
Published in:Future journal of pharmaceutical sciences 2022-12, Vol.8 (1), p.1-12, Article 53
Main Authors: Daniel, Augustine Innalegwu, Gara, Theresa Yebo, Atolagbe, Solomon Oluwafemi, Agboola, Aleemat Motunrayo, Salisu, Firdausi Emoshioke, Tsado, Rhoda, Fadaka, Adewale Oluwaseun, Mavumengwana, Vuyo, Keyster, Marshall, Klein, Ashwil
Format: Article
Language:English
Subjects:
Antidiabetics
Antioxidants
Cholesterol
Drugs
Flavonoids
Fractions
Gestational diabetes
Herbal medicine
High density lipoprotein
Hypoglycemia
Hypoglycemic
Hypolipidemic
Laboratories
Medicine
Medicine & Public Health
Nelsonia canescens
Oxidative stress
Pharmaceutical sciences
Phenols
Phytochemicals
Reagents
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Summary:Background Diabetes mellitus is a metabolic disorder that affects the body’s ability to produce or use insulin. There is a continuous rise of this disease particularly in developing countries due to changes in life style and poverty among the people. In this study, antidiabetic activities of aqueous extract of Nelsonia canescens and its partitioned fractions in alloxan-induced diabetic rats were evaluated. Male albino rats were divided into 9 groups (diabetic and non-diabetic) of 5 rats each. Diabetes was induced by single intraperitoneal administration of alloxan (90 mg/kgbwt). The experimental design consists of a diabetic control group (untreated), a normal control group (1 mL saline), a standard diabetic drug (Glibenclamide; 5 mg/kgbwt), two doses (50 and 300 mg/kgbwt) of aqueous extract, ethyl acetate and methanol fractions of Nelsonia canescens were orally administered for a period 21 days. Blood glucose of the rats was monitored at 3-days intervals while biochemical and in vivo antioxidant assays of serum and liver were determined after 21 days. Results The hypoglycemic effect of the extract observed was in a dose dependent manner with a significant reduction ( p   aqueous extract > methanol fraction compared with the diabetic control group. A significant difference ( p  
ISSN:2314-7253
2314-7245
2314-7253
DOI:10.1186/s43094-022-00445-1