Decreased Serum 25-hydroxyvitamin D Level Causes Interventricular Septal Hypertrophy in Patients on Peritoneal Dialysis: Cardiovascular Aspects of Endogenous Vitamin D Deficiency

Introduction. In the present study, we aimed to analyze the relation of vitamin D with echocardiographic indexes in patients with end stage renal disease (ESRD) receiving renal replacement therapy (RRT). Methods. A total of 98 patients, 64 patients on hemodialysis (HD) (29F/35M, mean age 56.75 ± 18....

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Published in:International Journal of Nephrology 2016-01, Vol.2016 (2016), p.40-45
Main Authors: Seyahi, Nurhan, Kahvecioglu, Serdar, Yılmaz, Mürvet, Harmankaya, Özlem, Saglam Gokmen, Emel, Atay, Ahmet Engin, Sahin, Irfan, Esen, Bennur, Kucuk, Suat Hayri
Format: Article
Language:English
Subjects:
Alfacalcidol
Calcifediol
Care and treatment
Chronic kidney failure
Continuous ambulatory peritoneal dialysis
Diagnosis
Health aspects
Hypertrophy
Patient outcomes
Peritoneal dialysis
Physiological aspects
Risk factors
Vitamin D
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Summary:Introduction. In the present study, we aimed to analyze the relation of vitamin D with echocardiographic indexes in patients with end stage renal disease (ESRD) receiving renal replacement therapy (RRT). Methods. A total of 98 patients, 64 patients on hemodialysis (HD) (29F/35M, mean age 56.75 ± 18.63 years) and 34 age matched patients on peritoneal dialysis (PD) (21F/13M, mean age 58.11 ± 10.63 years), with similar duration of ESRD and RRT were enrolled into this cross-sectional study. Echocardiographic examination was performed after dialysis session at normovolemic status. Fasting blood samples were obtained before dialysis session. Results. Patients on PD and female patients in both groups had significantly lower level of 25-OH-D3 level when compared to patients on HD or male patients (p: 0.0001 and p: 0.0001). When all participants were considered, there was no significant association between 25-OH-D3 and echocardiographic parameters; however, in patients on PD, a significant negative correlation was determined between 25-OH-D3 and diastolic blood pressure, interventricular septal hypertrophy (ISH), and left ventricular mass index (LVMI) (r: −0.424, p: 0.012; r: −0.508, p: 0.004; r: 0.489, p: 0.04, resp.). Conclusion. Low serum 25-hydroxyvitamin D levels is associated with ISH and LVMI in PD patients.
ISSN:2090-2158
2090-214X
2090-2158
DOI:10.1155/2016/2464953