Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants

Basic leucine zipper (bZIP) transcription factors control important developmental and physiological processes in plants. In Arabidopsis thaliana , the three gene F-bZIP subfamily has been associated with zinc deficiency and salt stress response. Benefiting from the present abundance of plant genomic...

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Bibliographic Details
Published in:Scientific reports 2017-06, Vol.7 (1), p.3806-14, Article 3806
Main Authors: Castro, Pedro Humberto, Lilay, Grmay H., Muñoz-Mérida, Antonio, Schjoerring, Jan K., Azevedo, Herlânder, Assunção, Ana G. L.
Format: Article
Language:English
Subjects:
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Abiotic stress
Divergence
Humanities and Social Sciences
Leucine zipper proteins
multidisciplinary
Nutrient deficiency
Phylogeny
Promoters
Science
Science (multidisciplinary)
Stress response
Transcription activation
Transcription factors
Zinc
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Summary:Basic leucine zipper (bZIP) transcription factors control important developmental and physiological processes in plants. In Arabidopsis thaliana , the three gene F-bZIP subfamily has been associated with zinc deficiency and salt stress response. Benefiting from the present abundance of plant genomic data, we performed an evolutionary and structural characterization of plant F-bZIPs. We observed divergence during seed plant evolution, into two groups and inferred different selective pressures for each. Group 1 contains AtbZIP19 and AtbZIP23 and appears more conserved, whereas Group 2, containing AtbZIP24, is more prone to gene loss and expansion events. Transcriptomic and experimental data reinforced AtbZIP19/23 as pivotal regulators of the zinc deficiency response, mostly via the activation of genes from the ZIP metal transporter family, and revealed that they are the main regulatory switch of AtZIP4 . A survey of AtZIP4 orthologs promoters across different plant taxa revealed an enrichment of the Zinc Deficiency Response Element ( ZDRE ) to which both AtbZIP19/23 bind. Overall, our results indicate that while the AtbZIP24 function in the regulation of the salt stress response may be the result of neo-functionalization, the AtbZIP19/23 function in the regulation of the zinc deficiency response may be conserved in land plants (Embryophytes).
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-03903-6