Revolutionizing Healthcare through Applications and Challenges of Nanomaterials in Targeted Drug Delivery and Therapeutics

• Published in: E3S web of conferences 2024-01, Vol.511, p.1002
• Main Authors: Verma, Rajan, Chowdhury, Sohini, Yadav, Rajat, Verma, Rajesh Prasad, Shrivastava, Anurag, Kumar, Mukesh, Khan, Akhilesh Kumar
• Format: Article
• Language: English
• Subjects: gold nanoparticles; liposomes; nanomaterials; targeted drug delivery; therapeutics
• ISSN: 2267-1242; 2267-1242
• DOI: 10.1051/e3sconf/202451101002

This research investigates the cutting edge of healthcare advancement through the applications and challenges of nanomaterials focused on sedate conveyance and therapeutics. Gold nanoparticles (AuNPs) and liposomes were synthesized, characterized, and utilized as carriers for doxorubicin, illustrating remarkable medicate stacking capacities of 4.5% and 80.2%, individually. The discharge energy uncovered a Higuchi demonstration for AuNPs and first-order energy for liposomes, exhibiting custom-fitted medicate discharge profiles. In vitro studies illustrated critical cytotoxicity, with an IC50 of 12.3 µM for AuNPs in A549 cells and 8.7 µM for liposomes in MCF-7 cells. Cellular take-up rates of 35.6% and 50.2% advance asserted their adequacy. Moving to in vivo studies, the circulation half-life of AuNPs was 6.2 hours, whereas liposomes displayed a longer half-life of 8.5 hours. Bio distribution ponders illustrated particular aggregation within the tumor, coming to 4.8% ID/g for AuNPs and 6.2% ID/g for liposomes. Helpful results included tumor measure decrease and by and large survival rates of 75.4% for AuNPs and 82.7% for liposomes. Comparison with related works highlighted the competitive execution of the created nanomaterials, emphasizing their potential in progressing exactness medication. This research contributes to the advancing scene of nanomedicine, emphasizing personalized and maintainable healthcare arrangements.