Functional impact of exercise pulmonary hypertension in patients with borderline resting pulmonary arterial pressure

Borderline resting mean pulmonary arterial pressure (mPAP) is associated with adverse outcomes and affects the exercise pulmonary vascular response. However, the pathophysiological mechanisms underlying exertional intolerance in borderline mPAP remain incompletely characterized. In the current study...

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Bibliographic Details
Published in:Pulmonary circulation 2017-07, Vol.7 (3), p.654-665
Main Authors: Oliveira, Rudolf K. F., Faria-Urbina, Mariana, Maron, Bradley A., Santos, Mario, Waxman, Aaron B., Systrom, David M.
Format: Article
Language:English
Subjects:
exercise
Maximum oxygen consumption
oxygen delivery
oxygen uptake
pathophysiology
Pulmonary hypertension
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Summary:Borderline resting mean pulmonary arterial pressure (mPAP) is associated with adverse outcomes and affects the exercise pulmonary vascular response. However, the pathophysiological mechanisms underlying exertional intolerance in borderline mPAP remain incompletely characterized. In the current study, we sought to evaluate the prevalence and functional impact of exercise pulmonary hypertension (ePH) across a spectrum of resting mPAP’s in consecutive patients with contemporary resting right heart catheterization (RHC) and invasive cardiopulmonary exercise testing. Patients with resting mPAP
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1177/2045893217709025