Updated advances of linking psychosocial factors and sex hormones with systemic lupus erythematosus susceptibility and development

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that primarily affects women, especially those of reproductive age. Genetics, environment, and gene-environment interactions play key roles in the development of SLE. Despite the numerous susceptibility genes of SLE identified to da...

Full description

Saved in:
Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2019-06, Vol.7, p.e7179-e7179, Article e7179
Main Authors: Pan, Qingjun, Chen, Xiaoqun, Liao, Shuzhen, Chen, Xiaocui, Zhao, Chunfei, Xu, Yong-Zhi, Liu, Hua-Feng
Format: Article
Language:English
Subjects:
Alexithymia
Allergy and Clinical Immunology
Androgens
Anxiety
Autoimmune diseases
B cells
Depression (Mood disorder)
Development and progression
Disease susceptibility
Emotions
Estrogens
Gene therapy
Genes
Genetic aspects
Hormones
Immunology
Lupus
Lupus erythematosus
Nephrology
Progesterone
Prolactin
Psychological aspects
Psychosocial factors
Rheumatology
Risk factors
Sex hormones
Social aspects
Stress (Psychology)
Systematic review
Systemic lupus erythematosus
Therapy targets
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that primarily affects women, especially those of reproductive age. Genetics, environment, and gene-environment interactions play key roles in the development of SLE. Despite the numerous susceptibility genes of SLE identified to date, gene therapy is far from a clinical reality. Thus, more attention should be paid to the risk factors and underlying mechanisms of SLE. Currently, it is reported that psychosocial factors and sex hormones play vital roles in patients with SLE, which still need further investigated. The purpose of this review is to update the roles and mechanisms of psychosocial factors and sex hormones in the susceptibility and development of SLE. Based on review articles and reports in reputable peer-reviewed journals and government websites, this paper summarized psychosocial factors (e.g., alexithymia, depression, anxiety, negative emotions, and perceived stress) and sex hormones (e.g., estrogens, progesterone, androgens, and prolactin) involved in SLE. We further explore the mechanisms linking these factors with SLE susceptibility and development, which can guide the establishment of practical measures to benefit SLE patients and offer new ideas for therapeutic strategies.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.7179