Plant as an Alternative Source of Antifungals against Aspergillus Infections: A Review

species consists of a group of opportunistic fungi that is virulent when the immunity of the host is compromised. Among the various species, is the most prevalent species. However, the prevalence of fungal infections caused by non-fumigatus has been increasing. Polyenes, echinocandins and azoles are...

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Bibliographic Details
Published in:Plants (Basel) 2022-11, Vol.11 (22), p.3009
Main Authors: Tan, Lee Fang, Yap, Vi Lien, Rajagopal, Mogana, Wiart, Christophe, Selvaraja, Malarvili, Leong, Mun Yee, Tan, Puay Luan
Format: Article
Language:English
Subjects:
antifungal activity
Antifungal agents
Antimicrobial agents
Aspergillosis
Aspergillus
Azoles
Chronic illnesses
Chronic obstructive pulmonary disease
Coronaviruses
Diabetes
Drug delivery
Drug delivery systems
Echinocandins
Fungal infections
Fungi
Fungicides
Heterocyclic compounds
Medicinal plants
Metabolites
Natural products
opportunistic infections
Plant extracts
plants
Polyenes
Review
Reviews
Severe acute respiratory syndrome coronavirus 2
Side effects
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Summary:species consists of a group of opportunistic fungi that is virulent when the immunity of the host is compromised. Among the various species, is the most prevalent species. However, the prevalence of fungal infections caused by non-fumigatus has been increasing. Polyenes, echinocandins and azoles are the three main classes of antifungal agents being used for the treatment of aspergillosis. Nevertheless, the incidence of resistance towards these three classes has been rising over the years among several spp. The side effects associated with these conventional antifungal agents have also limited their usage. This urges the need for the discovery of a safe and effective antifungal agent, which presents a major challenge in medicine today. Plants present a rich source of bioactive molecules which have been proven effective against a wide range of infections and conditions. Therefore, this present review intends to examine the current literature available regarding the efficacy and mechanism of action of plant extracts and their compounds against spp. In addition, novel drug delivery systems of plant extracts against spp. were also included in this review.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants11223009