MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma

gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the gene as early as possible in neuroblastoma (NB); however, for patients with bone marrow (BM) metastasis who need chemotherapy before surgery, timely detection of the gene is not po...

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Bibliographic Details
Published in:Cancer cell international 2017-03, Vol.17 (1), p.43-43, Article 43
Main Authors: Yue, Zhi-Xia, Huang, Cheng, Gao, Chao, Xing, Tian-Yu, Liu, Shu-Guang, Li, Xing-Jun, Zhao, Qian, Wang, Xi-Si, Zhao, Wen, Jin, Mei, Ma, Xiao-Li
Format: Article
Language:English
Subjects:
Abdomen
Acetic acid
Age
Autonomic nervous system
Bioindicators
Biopsy
Bone marrow
Bone marrow metastasis
c-Myc protein
Cancer
Cell culture
Chemotherapy
Children
Chromosome 11
Chromosomes
Color
Data collection
Dehydrogenase
Deoxyribonucleic acid
Distilled water
DNA
Ethanol
Fluorescence
Fluorescence in situ hybridization
Health risks
Heterogeneity
Hybridization
In situ measurement
Inhibitors
Malignancy
Medical prognosis
Metastases
Metastasis
MYCN amplification
Nervous system
Neuroblastoma
Patients
Pediatrics
Primary Research
Probes
Quality control
Radiation therapy
Statistical analysis
Statistics
Surgery
Survival analysis
Sympathetic nervous system
Temperature effects
Transplantation
Tumors
Urine
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Description
Summary:gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the gene as early as possible in neuroblastoma (NB); however, for patients with bone marrow (BM) metastasis who need chemotherapy before surgery, timely detection of the gene is not possible due to the unavailability of primary tumors. gene status was evaluated in 81 BM metastases of NB by interphase fluorescence in situ hybridization (FISH) analysis of BM cells. The clinicobiological characteristics and prognostic impact of amplification in NB metastatic to BM were analyzed. amplification was found in 16% of patients with metastases, and the results were consistent with the primary tumors detected by pathological tissue FISH. amplification was associated with age, lactate dehydrogenase (LDH) levels and prognosis (  = 0.038,  
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-017-0412-z