Hydrazide–Hydrazones as Potential Antitubercular Agents: An Overview of the Literature (1999–2023)

Hydrazide–hydrazone derivatives are prevalent in numerous bioactive compounds, showcasing a diverse array of biological effects including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal properties. Consequently, numerous medicina...

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Bibliographic Details
Published in:SynOpen (2017) 2024-08, Vol.8 (3), p.173-184
Main Authors: Mali, Suraj N., Pandey, Anima, Shah, Umang, Jawarkar, Rahul D, Somani, Rakesh
Format: Article
Language:English
Subjects:
antituberculosis
hydrazide–hydrazone
recent advances
tuberculosis
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Summary:Hydrazide–hydrazone derivatives are prevalent in numerous bioactive compounds, showcasing a diverse array of biological effects including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal properties. Consequently, numerous medicinal chemists have undertaken the synthesis of various hydrazide–hydrazones, subjecting them to evaluation for their biological activities. Among these, antituberculosis activity stands out as a recurring focus in the scientific literature. This paper provides a comprehensive overview of research spanning the last 24 years (1999–2023), concentrating on the antituberculosis properties of hydrazide–hydrazone derivatives. The insights presented herein could serve as a valuable roadmap for the development of novel hydrazide–hydrazones with potential antimicrobial efficacy.
ISSN:2509-9396
2509-9396
DOI:10.1055/a-2367-6993