Early biomarkers of neurodevelopmental disorders in preterm infants: protocol for a longitudinal cohort study

IntroductionPreterm (PT) infants are at high likelihood for poor neurodevelopmental outcomes, including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and other neurodevelopmental disorders (NDDs), which could considerably impair the individuals’ functions throughout...

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Bibliographic Details
Published in:BMJ open 2023-06, Vol.13 (6), p.e070230-e070230
Main Authors: Zhao, Yilu, Liu, Yunfeng, Gao, Xuping, Wang, Dan, Wang, Ning, Xie, Rao, Tong, Xiaomei, He, Yong, Yang, Li
Format: Article
Language:English
Subjects:
Autism
Autism Spectrum Disorder - complications
Biomarkers
Brain research
Child
Child & adolescent psychiatry
Child, Preschool
Cohort analysis
Cohort Studies
Congenital diseases
Electroencephalography
Hospitals
Humans
Infant
Infant, Newborn
Infant, Premature
Longitudinal Studies
Neurodevelopmental disorders
Neurodevelopmental Disorders - epidemiology
Neuropsychology
paediatric radiology
Paediatrics
Pediatrics
Premature babies
Premature birth
Prospective Studies
psychiatry
Spectrum analysis
Teenagers
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Summary:IntroductionPreterm (PT) infants are at high likelihood for poor neurodevelopmental outcomes, including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and other neurodevelopmental disorders (NDDs), which could considerably impair the individuals’ functions throughout their whole life. The current cohort study aims to investigate adverse outcomes, especially NDDs, in PT children, and the related early aberrant brain developmental biomarkers.Methods and analysisThis is a prospective cohort study in Beijing, China. We plan to recruit 400 PT infants born at
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-070230