Recent Progresses in Non-Dialysis Chronic Kidney Disease Patients with Hyperkalemia: Outcomes and Therapeutic Strategies

Chronic kidney disease (CKD) affects about 10% of the world's population. Hyperkalemia is a life-threatening complication in patients with CKD, as it is associated with adverse cardiovascular and kidney outcomes. There are still many challenges and questions to address to improve the currently...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-02, Vol.59 (2), p.353
Main Authors: Tian, Ruixue, Li, Rongshan, Zhou, Xiaoshuang
Format: Article
Language:English
Subjects:
Cardiovascular disease
chronic kidney disease
Chronic kidney failure
Clinical medicine
Complications and side effects
Diabetes
Diuretics
Drug therapy
Electrocardiography
Food
Heart failure
Hemodialysis
Homeostasis
Humans
Hyperkalemia
Hypokalemia
Kidney
Kidney diseases
Mortality
Nonsteroidal anti-inflammatory drugs
Patient outcomes
Peritoneal dialysis
Polymers - therapeutic use
Potassium
Renal Insufficiency, Chronic - complications
Review
Risk factors
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Summary:Chronic kidney disease (CKD) affects about 10% of the world's population. Hyperkalemia is a life-threatening complication in patients with CKD, as it is associated with adverse cardiovascular and kidney outcomes. There are still many challenges and questions to address to improve the currently available therapeutic strategies to treat hyperkalemia, such as how to approach the emergency management of hyperkalemia. In recent years, in addition to novel oral potassium binders, great progress has been made in the application of novel kidney protective strategies, such as mineralocorticoid receptor antagonists and sodium-glucose cotransporter 2 inhibitors (SGLT2i) in hyperkalemia therapy. This review will discuss the recent advances from clinical trials in the effective management of hyperkalemia in non-dialysis CKD patients, enhancing the knowledge of physicians and internists concerning these newer agents and providing a helpful reference for clinical practice.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59020353