Research progress on hippocampal neurogenesis in autism spectrum disorder

ABSTRACT Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders with unclear etiology and significant heterogeneity that is emerging as a global public health concern. Increasing research suggests the involvement of hippocampal neurogenesis defects in the onset and developm...

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Bibliographic Details
Published in:Pediatric investigation 2024-09, Vol.8 (3), p.215-223
Main Authors: Chen, Mengxiang, Guo, Lanmin, Li, Qinghong, Yang, Shunbo, Li, Wei, Lai, Yanmei, Lv, Zhihai
Format: Article
Language:English
Subjects:
Autism
Autism spectrum disorder
Behavior
Biomarkers
Brain research
Brain-derived neurotrophic factor
Cognitive ability
Communication
Hippocampal neurogenesis
Hippocampus
Hypothalamus
Kinases
Memory
Morphology
Neurobiology
Neurogenesis
Neurological disorders
Neurosciences
Pathogenesis
Proteins
Review
Signal transduction
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Summary:ABSTRACT Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders with unclear etiology and significant heterogeneity that is emerging as a global public health concern. Increasing research suggests the involvement of hippocampal neurogenesis defects in the onset and development of ASD, drawing increasing amounts of attention to hippocampal neurogenesis issues in ASD. In this paper, we analyze relevant international studies on hippocampal neurogenesis in ASD, discuss the role of neurobiology in the pathogenesis of ASD, and explore the potential of improving hippocampal neurogenesis as a therapeutic approach for ASD. This review aims to provide new treatment perspectives and theoretical foundations for clinical practice. Hippocampal neurogenesis defects have been confirmed in both autism spectrum disorder (ASD) patients and ASD mouse models, and hippocampal neurogenesis‐based regenerative therapy proposed for the treatment of ASD.
ISSN:2574-2272
2096-3726
2574-2272
DOI:10.1002/ped4.12440