Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a rea...

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Bibliographic Details
Published in:International journal of nanomedicine 2018-01, Vol.13, p.3311-3327
Main Authors: Qing, Yun'an, Cheng, Lin, Li, Ruiyan, Liu, Guancong, Zhang, Yanbo, Tang, Xiongfeng, Wang, Jincheng, Liu, He, Qin, Yanguo
Format: Article
Language:English
Subjects:
Analysis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibacterial mechanism
Antibiotics
Bacteria
Biocompatibility
Biofilms
Biofilms - drug effects
Biosynthesis
Bone surgery
Bones
Cell Adhesion - drug effects
Cell Differentiation - drug effects
Cytotoxicity
Deoxyribonucleic acid
DNA
Drug resistance
Enzymes
Fatalities
Gram-negative bacteria
Gram-positive bacteria
Health aspects
Humans
Infection
Infection control
Lipids
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Methicillin
Microorganisms
Nanoparticles
Orthopedic Equipment
Orthopedic implants
Orthopedic surgery
Osteogenic related cells
Prostheses and Implants
Proteins
Review
Silver
Silver - chemistry
Silver - pharmacology
Silver nanoparticles
Staphylococcus infections
Surface modification
Surgery
Technology
Titanium alloys
Transplants & implants
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Summary:Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/ijn.s165125