Impact of Spirometrically Confirmed Chronic Obstructive Pulmonary Disease on Arterial Stiffness and Surfactant Protein D After Percutaneous Coronary Intervention. The CATEPOC Study

Background: Several mechanisms have been proposed to explain why chronic obstructive pulmonary disease (COPD) impairs the prognosis of coronary events. We aimed to explore COPD variables related to a worse prognosis in patients undergoing percutaneous coronary intervention (PCI). Methods: Patients w...

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Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease 2022-01, Vol.17, p.2577-2587
Main Authors: Malik, Komal, Diaz-Coto, Susana, de la Asunción Villaverde, Maria Jose, Martinez-Camblor, Pablo, Navarro-Rolon, Annie, Pujalte, Francisco, De la Sierra, Alejandro, Almagro, Pere
Format: Article
Language:English
Subjects:
acute coronary event
Airway management
Analysis
Angioplasty
Ankle
arterial stiffness
Biomarkers
Blood
Cardiac patients
Cardiovascular disease
Care and treatment
Chronic illnesses
Chronic obstructive pulmonary disease
Comorbidity
Confidence intervals
Creatinine
Enzyme-linked immunosorbent assay
Heart attacks
ischaemic heart disease
Lung diseases, Obstructive
Mortality
Original Research
percutaneous coronary intervention
Prognosis
Proteins
Spirometry
Statistical analysis
Surface active agents
surfactant protein d
Surfactants
Transluminal angioplasty
Urine
Variables
Wave propagation
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Summary:Background: Several mechanisms have been proposed to explain why chronic obstructive pulmonary disease (COPD) impairs the prognosis of coronary events. We aimed to explore COPD variables related to a worse prognosis in patients undergoing percutaneous coronary intervention (PCI). Methods: Patients with an acute coronary event treated by PCI were prospectively included. One month after discharge, clinical characteristics, comorbidities measured with the Charlson index, and prognostic coronary scales (logistic EuroSCORE; GRACE 2.0) were collected. Post-bronchodilator spirometry, arterial stiffness, and serum inflammatory and myocardial biomarkers were measured. Lung plasmatic biomarkers (Surfactant protein D, desmosine, and Clara cell secretory protein-16) were determined with ELISA. COPD was defined by the fixed ratio (FEV1/FVC
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S373853