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A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections
Objectives While physicians are often confronted with immunoglobulin A (IgA) deficiency in children with recurrent infections, the clinical relevance of this finding is unclear. Large‐scale studies examining the significance of IgA deficiency in children are hampered by differences in techniques for...
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| Published in: | Clinical & translational immunology 2021, Vol.10 (11), p.e1344-n/a |
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| creator | Koenen, Mischa H Bosma, Madeleen Roorda, Udo A Wopereis, Fabiënne MY Roos, Anja der Vries, Erhard Bogaert, Debby Sanders, Elisabeth AM Boes, Marianne Heidema, Jojanneke Montfrans, Joris M Balemans, Walter AF Holten, Thijs C Verhagen, Lilly M |
| description | Objectives
While physicians are often confronted with immunoglobulin A (IgA) deficiency in children with recurrent infections, the clinical relevance of this finding is unclear. Large‐scale studies examining the significance of IgA deficiency in children are hampered by differences in techniques for measuring IgA and the physiological increase of IgA with age. Both result in a variety of reference values used for diagnosing IgA deficiency. We propose a new laboratory‐independent method to accurately compare IgA measurements in children of varying ages.
Methods
We present a method to standardise IgA values for age and laboratory differences. We applied this method to a multicentre case–control study of children under the age of seven suffering from recurrent respiratory tract infections (rRTI, cases) and children who had IgA measured as part of coeliac disease screening (controls). We defined IgA deficiency as serum IgA measurements |
| doi_str_mv | 10.1002/cti2.1344 |
| format | article |
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While physicians are often confronted with immunoglobulin A (IgA) deficiency in children with recurrent infections, the clinical relevance of this finding is unclear. Large‐scale studies examining the significance of IgA deficiency in children are hampered by differences in techniques for measuring IgA and the physiological increase of IgA with age. Both result in a variety of reference values used for diagnosing IgA deficiency. We propose a new laboratory‐independent method to accurately compare IgA measurements in children of varying ages.
Methods
We present a method to standardise IgA values for age and laboratory differences. We applied this method to a multicentre case–control study of children under the age of seven suffering from recurrent respiratory tract infections (rRTI, cases) and children who had IgA measured as part of coeliac disease screening (controls). We defined IgA deficiency as serum IgA measurements < 2.5% for age‐specific reference values.
Results
We developed reference values for IgA for seven age groups and five different laboratory assays. Using these reference values, IgA measurements from 417 cases and 224 controls were standardised to compare groups. In children aged 2 years and older, IgA deficiency was observed in 2.9% (7/242) of cases and 0% (0/189) of controls (P = 0.02).
Conclusion
We present a method to compare IgA values in cohorts that vary in age and laboratory assay. This way, we showed that IgA deficiency was more prevalent in children with rRTI compared with controls. This implicates that IgA deficiency may be a clinically relevant condition, even in young children.
With our method to standardize IgA values for laboratory and age differences, we show that IgA deficiency is more prevalent in children less than 7 years of age with recurrent respiratory infections compared with controls, implicating the clinical relevance.</description><identifier>ISSN: 2050-0068</identifier><identifier>EISSN: 2050-0068</identifier><identifier>DOI: 10.1002/cti2.1344</identifier><identifier>PMID: 34745609</identifier><language>eng</language><publisher>Australia: John Wiley & Sons, Inc</publisher><subject>Age ; Asymptomatic ; case–control study ; Celiac disease ; Children ; IgA deficiency ; Immunoglobulin A ; Immunoglobulins ; Infections ; Laboratories ; Original ; reference values ; Respiratory tract diseases ; Respiratory tract infection ; respiratory tract infections</subject><ispartof>Clinical & translational immunology, 2021, Vol.10 (11), p.e1344-n/a</ispartof><rights>2021 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc</rights><rights>2021 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5094-5d9e106f78cc233583f34fa01067ac00db7095164d5f5a2af34a2a944f00c48c3</citedby><cites>FETCH-LOGICAL-c5094-5d9e106f78cc233583f34fa01067ac00db7095164d5f5a2af34a2a944f00c48c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2601920801/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2601920801?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,11562,25753,27923,27924,27925,37012,37013,44590,46052,46476,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34745609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koenen, Mischa H</creatorcontrib><creatorcontrib>Bosma, Madeleen</creatorcontrib><creatorcontrib>Roorda, Udo A</creatorcontrib><creatorcontrib>Wopereis, Fabiënne MY</creatorcontrib><creatorcontrib>Roos, Anja</creatorcontrib><creatorcontrib>der Vries, Erhard</creatorcontrib><creatorcontrib>Bogaert, Debby</creatorcontrib><creatorcontrib>Sanders, Elisabeth AM</creatorcontrib><creatorcontrib>Boes, Marianne</creatorcontrib><creatorcontrib>Heidema, Jojanneke</creatorcontrib><creatorcontrib>Montfrans, Joris M</creatorcontrib><creatorcontrib>Balemans, Walter AF</creatorcontrib><creatorcontrib>Holten, Thijs C</creatorcontrib><creatorcontrib>Verhagen, Lilly M</creatorcontrib><title>A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections</title><title>Clinical & translational immunology</title><addtitle>Clin Transl Immunology</addtitle><description>Objectives
While physicians are often confronted with immunoglobulin A (IgA) deficiency in children with recurrent infections, the clinical relevance of this finding is unclear. Large‐scale studies examining the significance of IgA deficiency in children are hampered by differences in techniques for measuring IgA and the physiological increase of IgA with age. Both result in a variety of reference values used for diagnosing IgA deficiency. We propose a new laboratory‐independent method to accurately compare IgA measurements in children of varying ages.
Methods
We present a method to standardise IgA values for age and laboratory differences. We applied this method to a multicentre case–control study of children under the age of seven suffering from recurrent respiratory tract infections (rRTI, cases) and children who had IgA measured as part of coeliac disease screening (controls). We defined IgA deficiency as serum IgA measurements < 2.5% for age‐specific reference values.
Results
We developed reference values for IgA for seven age groups and five different laboratory assays. Using these reference values, IgA measurements from 417 cases and 224 controls were standardised to compare groups. In children aged 2 years and older, IgA deficiency was observed in 2.9% (7/242) of cases and 0% (0/189) of controls (P = 0.02).
Conclusion
We present a method to compare IgA values in cohorts that vary in age and laboratory assay. This way, we showed that IgA deficiency was more prevalent in children with rRTI compared with controls. This implicates that IgA deficiency may be a clinically relevant condition, even in young children.
With our method to standardize IgA values for laboratory and age differences, we show that IgA deficiency is more prevalent in children less than 7 years of age with recurrent respiratory infections compared with controls, implicating the clinical relevance.</description><subject>Age</subject><subject>Asymptomatic</subject><subject>case–control study</subject><subject>Celiac disease</subject><subject>Children</subject><subject>IgA deficiency</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Original</subject><subject>reference values</subject><subject>Respiratory tract diseases</subject><subject>Respiratory tract infection</subject><subject>respiratory tract infections</subject><issn>2050-0068</issn><issn>2050-0068</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kk1rGzEQhpfS0oQ0h_6BIuilPTgZ7Ur7cSkY0w9DoJf0LLTSyJbZlVxJa-O_k19a2U5DUuhFGs088zKvmKJ4T-GGApS3KtnyhlaMvSouS-AwA6jb18_ii-I6xg0AZAg4rd8WFxVrGK-huywe5sT5HQ5kxLT2miRPYpJOy6BtRBIxTCNZrua5LuMUcESXIolrv49EOmKdCrmAmmwD7uSATiHx5tSh0Vhlc-aQMXLwk1sRtbaDDujI3qY1CaimkF8pR3Frg0w-HEgKUqXcYjBb8y6-K94YOUS8fryvil_fvt4vfszufn5fLuZ3M8WhYzOuO6RQm6ZVqqwq3lamYkZCzjVSAei-gS7bZ5obLkuZq_nsGDMAirWquiqWZ13t5UZsgx1lOAgvrTglfFgJGZJVAwrVcmgVb1puKOsZ9l1fY48V10w3NdZZ68tZazv1I2qVPQY5vBB9WXF2LVZ-J1rOa8poFvj0KBD87wljEqONCodBOvRTFCXPXihr6yP68R9046fg8leJsgbaldDCkfp8plTwMQY0T8NQEMdFEsdFEsdFyuyH59M_kX_XJgO3Z2BvBzz8X0ks7pflSfIPJXvVJw</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Koenen, Mischa H</creator><creator>Bosma, Madeleen</creator><creator>Roorda, Udo A</creator><creator>Wopereis, Fabiënne MY</creator><creator>Roos, Anja</creator><creator>der Vries, Erhard</creator><creator>Bogaert, Debby</creator><creator>Sanders, Elisabeth AM</creator><creator>Boes, Marianne</creator><creator>Heidema, Jojanneke</creator><creator>Montfrans, Joris M</creator><creator>Balemans, Walter AF</creator><creator>Holten, Thijs C</creator><creator>Verhagen, Lilly M</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>2021</creationdate><title>A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections</title><author>Koenen, Mischa H ; Bosma, Madeleen ; Roorda, Udo A ; Wopereis, Fabiënne MY ; Roos, Anja ; der Vries, Erhard ; Bogaert, Debby ; Sanders, Elisabeth AM ; Boes, Marianne ; Heidema, Jojanneke ; Montfrans, Joris M ; Balemans, Walter AF ; Holten, Thijs C ; Verhagen, Lilly M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5094-5d9e106f78cc233583f34fa01067ac00db7095164d5f5a2af34a2a944f00c48c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Asymptomatic</topic><topic>case–control study</topic><topic>Celiac disease</topic><topic>Children</topic><topic>IgA deficiency</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Original</topic><topic>reference values</topic><topic>Respiratory tract diseases</topic><topic>Respiratory tract infection</topic><topic>respiratory tract infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koenen, Mischa H</creatorcontrib><creatorcontrib>Bosma, Madeleen</creatorcontrib><creatorcontrib>Roorda, Udo A</creatorcontrib><creatorcontrib>Wopereis, Fabiënne MY</creatorcontrib><creatorcontrib>Roos, Anja</creatorcontrib><creatorcontrib>der Vries, Erhard</creatorcontrib><creatorcontrib>Bogaert, Debby</creatorcontrib><creatorcontrib>Sanders, Elisabeth AM</creatorcontrib><creatorcontrib>Boes, Marianne</creatorcontrib><creatorcontrib>Heidema, Jojanneke</creatorcontrib><creatorcontrib>Montfrans, Joris M</creatorcontrib><creatorcontrib>Balemans, Walter AF</creatorcontrib><creatorcontrib>Holten, Thijs C</creatorcontrib><creatorcontrib>Verhagen, Lilly M</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Clinical & translational immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koenen, Mischa H</au><au>Bosma, Madeleen</au><au>Roorda, Udo A</au><au>Wopereis, Fabiënne MY</au><au>Roos, Anja</au><au>der Vries, Erhard</au><au>Bogaert, Debby</au><au>Sanders, Elisabeth AM</au><au>Boes, Marianne</au><au>Heidema, Jojanneke</au><au>Montfrans, Joris M</au><au>Balemans, Walter AF</au><au>Holten, Thijs C</au><au>Verhagen, Lilly M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections</atitle><jtitle>Clinical & translational immunology</jtitle><addtitle>Clin Transl Immunology</addtitle><date>2021</date><risdate>2021</risdate><volume>10</volume><issue>11</issue><spage>e1344</spage><epage>n/a</epage><pages>e1344-n/a</pages><issn>2050-0068</issn><eissn>2050-0068</eissn><abstract>Objectives
While physicians are often confronted with immunoglobulin A (IgA) deficiency in children with recurrent infections, the clinical relevance of this finding is unclear. Large‐scale studies examining the significance of IgA deficiency in children are hampered by differences in techniques for measuring IgA and the physiological increase of IgA with age. Both result in a variety of reference values used for diagnosing IgA deficiency. We propose a new laboratory‐independent method to accurately compare IgA measurements in children of varying ages.
Methods
We present a method to standardise IgA values for age and laboratory differences. We applied this method to a multicentre case–control study of children under the age of seven suffering from recurrent respiratory tract infections (rRTI, cases) and children who had IgA measured as part of coeliac disease screening (controls). We defined IgA deficiency as serum IgA measurements < 2.5% for age‐specific reference values.
Results
We developed reference values for IgA for seven age groups and five different laboratory assays. Using these reference values, IgA measurements from 417 cases and 224 controls were standardised to compare groups. In children aged 2 years and older, IgA deficiency was observed in 2.9% (7/242) of cases and 0% (0/189) of controls (P = 0.02).
Conclusion
We present a method to compare IgA values in cohorts that vary in age and laboratory assay. This way, we showed that IgA deficiency was more prevalent in children with rRTI compared with controls. This implicates that IgA deficiency may be a clinically relevant condition, even in young children.
With our method to standardize IgA values for laboratory and age differences, we show that IgA deficiency is more prevalent in children less than 7 years of age with recurrent respiratory infections compared with controls, implicating the clinical relevance.</abstract><cop>Australia</cop><pub>John Wiley & Sons, Inc</pub><pmid>34745609</pmid><doi>10.1002/cti2.1344</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| subjects | Age Asymptomatic case–control study Celiac disease Children IgA deficiency Immunoglobulin A Immunoglobulins Infections Laboratories Original reference values Respiratory tract diseases Respiratory tract infection respiratory tract infections |
| title | A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections |
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