Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib...

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Published in:Acta cirúrgica brasileira 2015-04, Vol.30 (4), p.270-276
Main Authors: Calistro Neto, José Pedro, Torres, Rômulo da Costa, Gonçalves, Giovanna Maria, Silva, Leopoldo Muniz da, Domingues, Maria Aparecida Custódio, Módolo, Norma Sueli Pinheiro, Barros, Guilherme Antonio Moreira de
Format: Article
Language:English
Subjects:
Ischemia
Kidney
Parecoxib
Rats
Reperfusion
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Summary:PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-865020150040000006