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Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice
This research aimed to investigate the immunomodulatory effects of phosphorylated polysaccharides (pRCPS) in immunosuppressed mice, improving their cellular and humoral immune function. Our results showed that pRCPS increased serum immunoglobulin (IgG, IgA, IgM) concentrations significantly, enhance...
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| Published in: | Molecules (Basel, Switzerland) Switzerland), 2019-11, Vol.24 (22), p.4150 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c493t-147f434c721e325913979a8a932d7f6153015f6b28c63a9eafea4522017018373 |
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| cites | cdi_FETCH-LOGICAL-c493t-147f434c721e325913979a8a932d7f6153015f6b28c63a9eafea4522017018373 |
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| container_issue | 22 |
| container_start_page | 4150 |
| container_title | Molecules (Basel, Switzerland) |
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| creator | Feng, Haibo Fan, Jing Lin, Lang Liu, Yunjie Chai, Dongkun Yang, Jie |
| description | This research aimed to investigate the immunomodulatory effects of phosphorylated
polysaccharides (pRCPS) in immunosuppressed mice, improving their cellular and humoral immune function. Our results showed that pRCPS increased serum immunoglobulin (IgG, IgA, IgM) concentrations significantly, enhanced splenocyte proliferation, and the thymus and spleen indices. pRCPS also promoted phagocytosis in peritoneal macrophages and enhanced cytokine (IFN-γ, IL-2, -4, -5, -6, and -10) serum levels. Importantly, pRCPS increased the proportions of selected T cell subpopulations (CD3
, CD4
, and the CD4
to CD8
ratio). Our results revealed that phosphorylation of the polysaccharides promoted their immune-enhancing effects. Thus, pRCPS can enhance cellular and humoral immunity and could be used as an immune-enhancing agent to overcome cyclophosphamide (CY)-induced immunosuppression. |
| doi_str_mv | 10.3390/molecules24224150 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_c86c8a83ead04b5cb5cb9969b54d115b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_c86c8a83ead04b5cb5cb9969b54d115b</doaj_id><sourcerecordid>2549051040</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-147f434c721e325913979a8a932d7f6153015f6b28c63a9eafea4522017018373</originalsourceid><addsrcrecordid>eNplkV9rFDEUxYMotlY_gC8y4PNq_s5MXgRZqi5ULKLP4U5y08kyMxmTmeJ-e7NuLS1CIOHec365ySHkNaPvhND0_RgHtOuAmUvOJVP0CTlnktONoFI_fXA-Iy9y3lPKWVE9J2eCNYK1gp-TuBvHdYpjdOsAS0yH6tJ7tEuuoq-u-5jnvhRLC131HVz4XW0PsPRFjEXhgw0TDCFX13E4ZLC2hxQc5ipM1Ymc13lOmHPxfw0WX5JnHoaMr-72C_Lz0-WP7ZfN1bfPu-3Hq42VWiwbJhsvhbQNZyi40kzoRkMLWnDX-JopQZnydcdbWwvQCB5BKs4pa2h5WCMuyO7EdRH2Zk5hhHQwEYL5W4jpxkBagh3Q2La2LbQCwVHZKXtcWte6U9IxprrC-nBizWs3orM4LQmGR9DHnSn05ibemrrVTMnjMG_vACn-WjEvZh_XVD4uG66kpopRSYuKnVQ2xZwT-vsbGDXHvM1_eRfPm4ej3Tv-BSz-AL_jquc</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2549051040</pqid></control><display><type>article</type><title>Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Feng, Haibo ; Fan, Jing ; Lin, Lang ; Liu, Yunjie ; Chai, Dongkun ; Yang, Jie</creator><creatorcontrib>Feng, Haibo ; Fan, Jing ; Lin, Lang ; Liu, Yunjie ; Chai, Dongkun ; Yang, Jie</creatorcontrib><description>This research aimed to investigate the immunomodulatory effects of phosphorylated
polysaccharides (pRCPS) in immunosuppressed mice, improving their cellular and humoral immune function. Our results showed that pRCPS increased serum immunoglobulin (IgG, IgA, IgM) concentrations significantly, enhanced splenocyte proliferation, and the thymus and spleen indices. pRCPS also promoted phagocytosis in peritoneal macrophages and enhanced cytokine (IFN-γ, IL-2, -4, -5, -6, and -10) serum levels. Importantly, pRCPS increased the proportions of selected T cell subpopulations (CD3
, CD4
, and the CD4
to CD8
ratio). Our results revealed that phosphorylation of the polysaccharides promoted their immune-enhancing effects. Thus, pRCPS can enhance cellular and humoral immunity and could be used as an immune-enhancing agent to overcome cyclophosphamide (CY)-induced immunosuppression.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules24224150</identifier><identifier>PMID: 31731832</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Antigens ; CD3 antigen ; CD4 antigen ; CD4-CD8 Ratio ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - pathology ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - pathology ; Cell growth ; Cyclophosphamide ; Cyclophosphamide - adverse effects ; Cyclophosphamide - pharmacology ; Cytokines - immunology ; Humoral immunity ; Immune response ; Immune system ; Immunity, Humoral - drug effects ; Immunocompromised Host ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulins - immunology ; Immunomodulation ; immunosuppressed mice ; Immunosuppression ; Immunotherapy ; Infections ; Infectious diseases ; Interleukin 2 ; Lymphocytes ; Lymphocytes T ; Macrophages ; Macrophages, Peritoneal - immunology ; Medical research ; Mice ; Mice, Inbred ICR ; Peritoneum ; Phagocytosis ; Phosphorylation ; phosphorylation modification ; polysaccharide ; Polysaccharides ; Polysaccharides - chemistry ; Polysaccharides - pharmacology ; radix cyathula officinalis kuan polysaccharide ; Ranunculaceae - chemistry ; Saccharides ; Serum levels ; Spleen ; Subpopulations ; Thymus gland ; γ-Interferon</subject><ispartof>Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4150</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-147f434c721e325913979a8a932d7f6153015f6b28c63a9eafea4522017018373</citedby><cites>FETCH-LOGICAL-c493t-147f434c721e325913979a8a932d7f6153015f6b28c63a9eafea4522017018373</cites><orcidid>0000-0003-1106-7588</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2549051040/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2549051040?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31731832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Haibo</creatorcontrib><creatorcontrib>Fan, Jing</creatorcontrib><creatorcontrib>Lin, Lang</creatorcontrib><creatorcontrib>Liu, Yunjie</creatorcontrib><creatorcontrib>Chai, Dongkun</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><title>Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>This research aimed to investigate the immunomodulatory effects of phosphorylated
polysaccharides (pRCPS) in immunosuppressed mice, improving their cellular and humoral immune function. Our results showed that pRCPS increased serum immunoglobulin (IgG, IgA, IgM) concentrations significantly, enhanced splenocyte proliferation, and the thymus and spleen indices. pRCPS also promoted phagocytosis in peritoneal macrophages and enhanced cytokine (IFN-γ, IL-2, -4, -5, -6, and -10) serum levels. Importantly, pRCPS increased the proportions of selected T cell subpopulations (CD3
, CD4
, and the CD4
to CD8
ratio). Our results revealed that phosphorylation of the polysaccharides promoted their immune-enhancing effects. Thus, pRCPS can enhance cellular and humoral immunity and could be used as an immune-enhancing agent to overcome cyclophosphamide (CY)-induced immunosuppression.</description><subject>Animals</subject><subject>Antigens</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD4-CD8 Ratio</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>Cell growth</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cyclophosphamide - pharmacology</subject><subject>Cytokines - immunology</subject><subject>Humoral immunity</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Humoral - drug effects</subject><subject>Immunocompromised Host</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulins - immunology</subject><subject>Immunomodulation</subject><subject>immunosuppressed mice</subject><subject>Immunosuppression</subject><subject>Immunotherapy</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interleukin 2</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Peritoneum</subject><subject>Phagocytosis</subject><subject>Phosphorylation</subject><subject>phosphorylation modification</subject><subject>polysaccharide</subject><subject>Polysaccharides</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - pharmacology</subject><subject>radix cyathula officinalis kuan polysaccharide</subject><subject>Ranunculaceae - chemistry</subject><subject>Saccharides</subject><subject>Serum levels</subject><subject>Spleen</subject><subject>Subpopulations</subject><subject>Thymus gland</subject><subject>γ-Interferon</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNplkV9rFDEUxYMotlY_gC8y4PNq_s5MXgRZqi5ULKLP4U5y08kyMxmTmeJ-e7NuLS1CIOHec365ySHkNaPvhND0_RgHtOuAmUvOJVP0CTlnktONoFI_fXA-Iy9y3lPKWVE9J2eCNYK1gp-TuBvHdYpjdOsAS0yH6tJ7tEuuoq-u-5jnvhRLC131HVz4XW0PsPRFjEXhgw0TDCFX13E4ZLC2hxQc5ipM1Ymc13lOmHPxfw0WX5JnHoaMr-72C_Lz0-WP7ZfN1bfPu-3Hq42VWiwbJhsvhbQNZyi40kzoRkMLWnDX-JopQZnydcdbWwvQCB5BKs4pa2h5WCMuyO7EdRH2Zk5hhHQwEYL5W4jpxkBagh3Q2La2LbQCwVHZKXtcWte6U9IxprrC-nBizWs3orM4LQmGR9DHnSn05ibemrrVTMnjMG_vACn-WjEvZh_XVD4uG66kpopRSYuKnVQ2xZwT-vsbGDXHvM1_eRfPm4ej3Tv-BSz-AL_jquc</recordid><startdate>20191115</startdate><enddate>20191115</enddate><creator>Feng, Haibo</creator><creator>Fan, Jing</creator><creator>Lin, Lang</creator><creator>Liu, Yunjie</creator><creator>Chai, Dongkun</creator><creator>Yang, Jie</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1106-7588</orcidid></search><sort><creationdate>20191115</creationdate><title>Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice</title><author>Feng, Haibo ; Fan, Jing ; Lin, Lang ; Liu, Yunjie ; Chai, Dongkun ; Yang, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-147f434c721e325913979a8a932d7f6153015f6b28c63a9eafea4522017018373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>CD3 antigen</topic><topic>CD4 antigen</topic><topic>CD4-CD8 Ratio</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>Cell growth</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Cyclophosphamide - pharmacology</topic><topic>Cytokines - immunology</topic><topic>Humoral immunity</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity, Humoral - drug effects</topic><topic>Immunocompromised Host</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulins - immunology</topic><topic>Immunomodulation</topic><topic>immunosuppressed mice</topic><topic>Immunosuppression</topic><topic>Immunotherapy</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interleukin 2</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Peritoneum</topic><topic>Phagocytosis</topic><topic>Phosphorylation</topic><topic>phosphorylation modification</topic><topic>polysaccharide</topic><topic>Polysaccharides</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - pharmacology</topic><topic>radix cyathula officinalis kuan polysaccharide</topic><topic>Ranunculaceae - chemistry</topic><topic>Saccharides</topic><topic>Serum levels</topic><topic>Spleen</topic><topic>Subpopulations</topic><topic>Thymus gland</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Haibo</creatorcontrib><creatorcontrib>Fan, Jing</creatorcontrib><creatorcontrib>Lin, Lang</creatorcontrib><creatorcontrib>Liu, Yunjie</creatorcontrib><creatorcontrib>Chai, Dongkun</creatorcontrib><creatorcontrib>Yang, Jie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Haibo</au><au>Fan, Jing</au><au>Lin, Lang</au><au>Liu, Yunjie</au><au>Chai, Dongkun</au><au>Yang, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2019-11-15</date><risdate>2019</risdate><volume>24</volume><issue>22</issue><spage>4150</spage><pages>4150-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>This research aimed to investigate the immunomodulatory effects of phosphorylated
polysaccharides (pRCPS) in immunosuppressed mice, improving their cellular and humoral immune function. Our results showed that pRCPS increased serum immunoglobulin (IgG, IgA, IgM) concentrations significantly, enhanced splenocyte proliferation, and the thymus and spleen indices. pRCPS also promoted phagocytosis in peritoneal macrophages and enhanced cytokine (IFN-γ, IL-2, -4, -5, -6, and -10) serum levels. Importantly, pRCPS increased the proportions of selected T cell subpopulations (CD3
, CD4
, and the CD4
to CD8
ratio). Our results revealed that phosphorylation of the polysaccharides promoted their immune-enhancing effects. Thus, pRCPS can enhance cellular and humoral immunity and could be used as an immune-enhancing agent to overcome cyclophosphamide (CY)-induced immunosuppression.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31731832</pmid><doi>10.3390/molecules24224150</doi><orcidid>https://orcid.org/0000-0003-1106-7588</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4150 |
| issn | 1420-3049 1420-3049 |
| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Animals Antigens CD3 antigen CD4 antigen CD4-CD8 Ratio CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell growth Cyclophosphamide Cyclophosphamide - adverse effects Cyclophosphamide - pharmacology Cytokines - immunology Humoral immunity Immune response Immune system Immunity, Humoral - drug effects Immunocompromised Host Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins - immunology Immunomodulation immunosuppressed mice Immunosuppression Immunotherapy Infections Infectious diseases Interleukin 2 Lymphocytes Lymphocytes T Macrophages Macrophages, Peritoneal - immunology Medical research Mice Mice, Inbred ICR Peritoneum Phagocytosis Phosphorylation phosphorylation modification polysaccharide Polysaccharides Polysaccharides - chemistry Polysaccharides - pharmacology radix cyathula officinalis kuan polysaccharide Ranunculaceae - chemistry Saccharides Serum levels Spleen Subpopulations Thymus gland γ-Interferon |
| title | Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice |
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