Reactive oxygen species and sperm cells

There is a dynamic interplay between pro- and anti-oxidant substances in human ejaculate. Excessive reactive oxygen species (ROS) generation can overwhelm protective mechanism and initiate changes in lipid and/or protein layers of sperm plasma membranes. Additionally, changes in DNA can be induced....

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2004-03, Vol.2 (1), p.12-12, Article 12
Main Authors: Sanocka, Dorota, Kurpisz, Maciej
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Free Radicals - metabolism
Humans
Lipid Peroxidation
Male
Membrane Lipids - metabolism
Reactive Oxygen Species - metabolism
Review
Spermatozoa - cytology
Spermatozoa - metabolism
Spermatozoa - physiology
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Summary:There is a dynamic interplay between pro- and anti-oxidant substances in human ejaculate. Excessive reactive oxygen species (ROS) generation can overwhelm protective mechanism and initiate changes in lipid and/or protein layers of sperm plasma membranes. Additionally, changes in DNA can be induced. The essential steps of lipid peroxidation have been listed as well as antioxidant substances of semen. A variety of detection techniques of lipid peroxidation have been summarized together with the lipid components of sperm membranes that can be subjected to stress. It is unsolved, a threshold for ROS levels that may induce functional sperm ability or may lead to male infertility.
ISSN:1477-7827
1477-7827
DOI:10.1186/1477-7827-2-12