Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice

The role of inulin in alleviating obesity-related disorders has been documented; yet, its underlying mechanisms still need to be further investigated. This study attempted to elucidate the causative link between the gut microbiota and the beneficial effect of inulin on obesity-related disorders via...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-05, Vol.28 (10), p.3997
Main Authors: Huang, Yinli, Ying, Na, Zhao, Qihui, Chen, Junli, Teow, Sin-Yeang, Dong, Wei, Lin, Minjie, Jiang, Lingling, Zheng, Hong
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bifidobacterium
Body weight
Calories
Cluster analysis
Dextrose
Diet
Diet, High-Fat - adverse effects
Discriminant analysis
Fecal Microbiota Transplantation
Fecal microflora
Feces
Glucose
Glucose metabolism
gut microbiota
High fat diet
Homeostasis
Inflammation
Insulin
Intestinal microflora
Inulin
Inulin - pharmacology
liver
Metabolism
Mice
Mice, Inbred C57BL
Mice, Obese
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Obesity
Obesity - metabolism
Physiological aspects
Transplantation
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Summary:The role of inulin in alleviating obesity-related disorders has been documented; yet, its underlying mechanisms still need to be further investigated. This study attempted to elucidate the causative link between the gut microbiota and the beneficial effect of inulin on obesity-related disorders via transferring the fecal microbiota from inulin-dosed mice to high-fat diet (HFD)-induced obese recipient mice. The results show that inulin supplementation can decrease body weight, fat accumulation, and systemic inflammation and can also enhance glucose metabolism in HFD-induced obese mice. Treatment with inulin reshaped the structure and composition of the gut microbiota in HFD-induced obese mice, as characterized by increases in the relative abundances of and and decreases in and . In addition, we found that these favorable effects of inulin could be partially transferable by fecal microbiota transplantation, and and might be the key bacterial genera. Therefore, our results suggest that inulin ameliorates obesity-related disorders by targeting the gut microbiota.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28103997