Relationships between High-mobility Group Protein B1 and Triggering Receptor Expressed on Myeloid Cells Concentrations in Gingival Crevicular Fluid and Chronic Periodontitis

One of the inflammatory mediators which is secreted by inflammatory cells is high-mobility group protein B1 (HMGB1). Interaction of HMGB1 and toll-like receptors (TLRs) leads to increased production of inflammatory cytokines. On the other hand, it was shown that triggering receptor expressed on myel...

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Bibliographic Details
Published in:Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2016-10, Vol.15 (5), p.381-385
Main Authors: Paknejad, Mojgan, Sattari, Mandana, Roozbahani, Zohreh, Ershadi, Morteza, Mehrfard, Ali
Format: Article
Language:English
Subjects:
Adult
Alarmins
Chronic periodontitis
Chronic Periodontitis - immunology
Chronic Periodontitis - pathology
DAMP
Disease
Enzyme-linked immunosorbent assay
Female
Gene expression
Gingiva
Gingiva - immunology
Gingiva - pathology
Gum disease
High-mobility group protein
HMGB1
HMGB1 protein
HMGB1 Protein - immunology
Humans
Inflammation
Inflammatory diseases
Male
Membrane Glycoproteins - immunology
Middle Aged
Mobility
Myeloid cells
Periodontal diseases
Periodontitis
Receptors, Immunologic - immunology
Studies
Toll-like receptors
Triggering Receptor Expressed on Myeloid Cells-1
Womens health
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Summary:One of the inflammatory mediators which is secreted by inflammatory cells is high-mobility group protein B1 (HMGB1). Interaction of HMGB1 and toll-like receptors (TLRs) leads to increased production of inflammatory cytokines. On the other hand, it was shown that triggering receptor expressed on myeloid cells (TREM-1) also can be activated by TLRs, and its soluble form (sTREM-1) can be formed by cleaving of membrane-bound form of TREM-1 proteinases. Since there is not enough knowledge about the precise role of HMGB1 and sTREM-1 in periodontal diseases, the aim of this study was to evaluate the concentration of HMGB1 and sTREM-1 in gingival crevicular fluid (GCF) samples of patients with chronic periodontitis. Gingival crevicular fluid (GCF) samples were obtained from a total of 24 individuals with clinically healthy gingiva and 24 patients with moderate to severe chronic periodontitis. For collecting GCF samples, periopapers were placed at the entrance of the crevice and left in position for 30 seconds. Then, they were stored at -80°C. Enzyme-linked immunosorbent assay (ELISA) was used for measuring the concentration of HMGB1 and sTREM-1 in GCF samples. The concentration of HMGB1 (p
ISSN:1735-1502
1735-5249