Non-Hodgkin's lymphoma with extensive emperipolesis mimicking Rosai-Dorfman disease: A rare case report

Emperipolesis is the hallmark finding for Rosai-Dorfman disease. Till now many studies in literatures have shown emperipolesis as a finding in other benign as well as malignant conditions. Very few cases of malignant lymphoma have this phenomenon. Herewith, we put forward a rare case of lymphoma wit...

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Bibliographic Details
Published in:Indian journal of pathology & microbiology 2019-04, Vol.62 (2), p.319-322
Main Authors: Rane, Sharada, Parkhi, Mayur, Vishwasrao, Sharvari, Nakate, Leena
Format: Article
Language:English
Subjects:
Abdomen
Biomarkers
Bone marrow
Cancer cells
Case reports
Cecum
Cellular biology
Colectomy
Consent
CT imaging
Cytoplasm
Diagnosis, Differential
Differential diagnosis
Emperipolesis
Histiocytes - pathology
Histiocytosis
Histiocytosis, Sinus - diagnosis
Histiocytosis, Sinus - pathology
Humans
Immunohistochemistry
Leukemia
Light microscopy
Liver
Liver - pathology
Liver - surgery
Lymph nodes
Lymph Nodes - pathology
Lymphatic system
Lymphoid cells
Lymphoma
Lymphoma, Non-Hodgkin - complications
Lymphoma, Non-Hodgkin - diagnosis
Male
Middle Aged
Mimicry
Multiple myeloma
Neuroblastoma
Non-Hodgkin's lymphoma
Non-Hodgkin's lymphomas
Rosai–Dorfman disease
Spleen
Spleen - abnormalities
Spleen - pathology
Splenectomy
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Description
Summary:Emperipolesis is the hallmark finding for Rosai-Dorfman disease. Till now many studies in literatures have shown emperipolesis as a finding in other benign as well as malignant conditions. Very few cases of malignant lymphoma have this phenomenon. Herewith, we put forward a rare case of lymphoma with clinical presentation showing involvement of spleen, liver, lymph nodes as well as lleo-cecal region. Light microscopy revealed large to medium sized lymphoid cells with intervening plenty of histiocytes showing evidence of emperipolesis that mimics Rosai Dorfmann disease. Due to atypical clinical presentations we thought of lymphoma as a differential diagnosis. Further immunohistochemistry was performed using histiocytic as well as lymphoid markers. To our surprise, it turns out to be Non Hodgkin Lymphoma with extensive emperipolesis which is extremely rare in thorough literature search. This case is presented due to its unique clinical as well as histological presentations.
ISSN:0377-4929
0974-5130
DOI:10.4103/IJPM.IJPM_409_18