Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans

Environmental conditions can cause phenotypic changes, part of which can be inherited by subsequent generations via soma-to-germline communication. However, the signaling molecules or pathways that mediate intertissue communication remain unclear. Here, we show that intertissue small RNA communicati...

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Bibliographic Details
Published in:Communications biology 2021-02, Vol.4 (1), p.207-207, Article 207
Main Authors: Okabe, Emiko, Uno, Masaharu, Kishimoto, Saya, Nishida, Eisuke
Format: Article
Language:English
Subjects:
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Biology
Biomedical and Life Sciences
Caenorhabditis elegans
Communication
Communications systems
Environmental conditions
Heredity
Hormesis
Intestine
Life Sciences
miRNA
Nematodes
RNA transport
siRNA
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Summary:Environmental conditions can cause phenotypic changes, part of which can be inherited by subsequent generations via soma-to-germline communication. However, the signaling molecules or pathways that mediate intertissue communication remain unclear. Here, we show that intertissue small RNA communication systems play a key role in the acquisition and inheritance of hormesis effects – stress-induced stress resistance – in Caenorhabditis elegans . The miRNA-processing enzyme DRSH-1 is involved in both the acquisition and the inheritance of hormesis, whereas worm-specific Argonaute (WAGO) proteins, which function with endo-siRNAs, are involved only in its inheritance. Further analyses demonstrate that the miRNA production system in the neuron and the small RNA transport machinery in the intestine are both essential for its acquisition and that both the transport of small RNAs in the germline and the germline Argonaute HRDE-1 complex are required for its inheritance. Our results thus demonstrate that overlapping and distinct roles of small RNA systems in the acquisition and inheritance of hormesis effects. Okabe et al. show that the miRNA production system in the neuron and the small RNA transport machinery in the intestine are required for the acquisition of hormesis. For its inheritance, both the transport of small RNAs in the germline and the germline Argonaute HRDE-1 complex are needed, highlighting distinct contribution of small RNA systems to hormesis.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-021-01692-3