The human kidney as a regulator of body cytokine homeostasis

Evidence is accumulating that the human kidney is a major site for the removal of several cytokines and growth factors, which can accumulate in body pools in patients with acute and chronic kidney disease (CKD). In addition, progressive renal failure and the increase in circulating proinflammatory c...

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Bibliographic Details
Published in:Journal of Biological Research 2011-01, Vol.84 (1), p.76-76
Main Authors: Bonanni, A, Sofia, A, Saffioti, S, Mannucci, I, Verzola, D, Gramegna, P, Cappuccino, L, Garibotto, G
Format: Article
Language:English
Subjects:
Cytokines
Diabetes mellitus (non-insulin dependent)
Homeostasis
Inflammation
inflammation, adipokines, Leptin, IL-6, chronic kidney disease
Interleukin 6
Kidney diseases
Leptin
Metabolic syndrome
Renal failure
Transforming growth factor-b
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Summary:Evidence is accumulating that the human kidney is a major site for the removal of several cytokines and growth factors, which can accumulate in body pools in patients with acute and chronic kidney disease (CKD). In addition, progressive renal failure and the increase in circulating proinflammatory cytokines are associated with mortality, suggesting that altered cytokines handling by the kidney is associated with worse outcome. Also, the kidney itself may be damaged by signals arising by endothelia and peripheral tissues during the course of the metabolic syndrome, type 2 diabetes and obesity. In this paper we provide a review of kidney handling of several adipokines and myokines, with special emphasis to interleukin-6 (IL-6), leptin, resistin and transforming growth factor-beta (TGF-beta).
ISSN:1826-8838
2284-0230
DOI:10.4081/jbr.2011.4498